ArticleApplied sciences (Basel, Switzerland)2019
A review on ultrasonic neuromodulation of the peripheral nervous system: enhanced or suppressed activities?
Article in Applied sciences (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.Acta biomaterialia · 2026Article
- Methods for quantitative analyses of nerve fiber deformation in the myenteric plexus under loading of mouse distal colon and rectum.Medical engineering & physics · 2025Article
- Low-Intensity ultrasound for controlled excitation and suppression in rat sciatic nerve.Scientific reports · 2025Article
- Research progress in different physical therapies for treating peripheral nerve injuries.Frontiers in neurology · 2025Review
- Reduction of Anxiety-Related Symptoms Using Low-Intensity Ultrasound Neuromodulation on the Auricular Branch of the Vagus Nerve: Preliminary Study.JMIR neurotechnology · 2025Article
- The dorsal root ganglion as a target for neurorestoration in neuropathic pain.Neural regeneration research · 2024Review
- Assessment of focused ultrasound stimulation to induce peripheral nerve activity and potential damageFrontiers in neurology · 2024Article
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Article
- Feature-aware unsupervised lesion segmentation for brain tumor images using fast data density functional transform.Scientific reports · 2023Article
- Peripheral focused ultrasound stimulation and its applications: From therapeutics to human-computer interaction.Frontiers in neuroscience · 2023Review
- Ultrasonic neuromodulation mediated by mechanosensitive ion channels: current and future.Frontiers in neuroscience · 2023Article
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- Ultrasound does not activate but can inhibit in vivo mammalian nerves across a wide range of parameters.Scientific reports · 2022Article
- Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review.Journal of neuroengineering and rehabilitation · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ultrasonic (US) neuromodulation has emerged as a promising therapeutic means by delivering focused energy deep into the tissue. Low-intensity ultrasound (US) directly activates and/or inhibits neurons in the central nervous system (CNS). US neuromodulation of the peripheral nervous system (PNS) is less developed and rarely used clinically. Literature on the neuromodulatory effects of US on the PNS is controversy with some documenting enhanced neural activities, some showing suppressed activities, and others reporting mixed effects. US, with different range of intensity and strength, is likely to generate distinct physical effects in the stimulated neuronal tissues, which underlies different experimental outcomes in the literature. In this review, we summarize all the major reports that documented the effects of US on peripheral nerve endings, axons, and/or somata in the dorsal root ganglion. In particular, we thoroughly discuss the potential impacts by the following key parameters to the study outcomes of PNS neuromodulation by the US: frequency, pulse repetition frequency, duty cycle, intensity, metrics for peripheral neural activities, and type of biological preparations used in the studies. Potential mechanisms of peripheral US neuromodulation are summarized to provide a plausible interpretation to the seemly contradictory effects of enhanced and suppressed neural activities from US neuromodulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.