SynthesisFrontiers in immunology2021
When the Good Syndrome Goes Bad: A Systematic Literature Review.
Synthesis in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
- Robotic subxiphoid-optical thymectomy for Good's syndrome in a severely immunocompromised patient: a case report.Translational lung cancer research · 2026Article
- Clinical characteristics and risk factors of cytomegalovirus infection in patients with good syndrome.BMC immunology · 2026Article
- Immunological spectrum in patients with thymoma: beyond good syndrome.Immunologic research · 2026Article
- Oligoclonal expansion of atypical Vδ2Nature communications · 2026Article
- Article
- Perioperative Management of a Patient with Good Syndrome and Pancytopenia Undergoing Sternotomy and Thymectomy.Annals of cardiac anaesthesia · 2026Article
- Severe SARS-CoV-2 Infection and Campylobacter coli Bacteremia in a Patient With Good's Syndrome.Cureus · 2025Article
- Article
- Missed and misdiagnosis of immunodeficiency: Good syndrome presenting as persistent COVID-19 shedding.Asia Pacific allergy · 2025Article
- Complex management of GS (Good's syndrome) with persistent COVID-19 infection and polymicrobial infections: A case report.Heliyon · 2025Article
- Good syndrome presenting with multiple pulmonary infections: a case report involving metagenomic sequencing diagnosis.Frontiers in medicine · 2025Article
- B cell deficiency in thymoma tissues of Good's syndrome patients.Discover oncology · 2024Article
- Association between Infection and Calculated Globulin Level among Patients with Thymic Epithelial Tumor.Journal of clinical medicine · 2024Article
- Thymoma with recurrent opportunistic infections-a case report.Oxford medical case reports · 2024Article
- Article
- A man with a right paratracheal mass and recurrent respiratory infections: Putting the pieces together.Lung India : official organ of Indian Chest Society · 2024Article
- Article
- COVID-19 in patients with thymic epithelial tumors with or without Good's syndrome: a single-center retrospective study.BMC cancer · 2024Article
- Thymoma with immunodeficiency, combined diffuse panbronchiolitis, and latent autoimmune diabetes in adults- case report and systematic review.Journal of translational autoimmunity · 2024Article
- Good's syndrome combined with CMV gastroenteritis: A case report and literature review.Clinical case reports · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Good syndrome is a rare adult-onset immunodeficiency characterized by thymoma and hypogammaglobulinemia. Its clinical manifestations are highly heterogeneous, ranging from various infections to autoimmunity. Objective: This study was to summarize patient characteristics, identify prognostic factors and define clinical subgroups of Good syndrome. Methods: A systematic literature review was conducted to include patients with Good syndrome identified in PubMed, Embase and Cochrane databases between January 2010 and November 2020. Logistic and Cox regressions were used to identify prognostic factors impacting outcomes. Clinical subgroups were defined by multiple correspondence analysis and unsupervised hierarchical clustering. A decision tree was constructed to characterize the subgroup placement of cases. Results: Of 162 patients included in the current study, the median age at diagnosis was 58 years and 51% were male. Type AB was the most common histological subtype of thymoma, and infections as well as concurrent autoimmune disorders were identified in 92.6% and 51.2% patients, respectively. Laboratory workup showed typical findings of combined immunodeficiency. Thymoma status (odds ratio [OR] 4.157, confidence interval [CI] 1.219-14.177, Conclusions: Infection type and site were the main prognostic factors impacting survival of patients with Good syndrome. We identified three subgroups within Good syndrome associated with distinct clinical features, which may facilitate the study of underlying pathogenesis as well as development of targeted therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.