Evidence map›Paper›PMID 34113232›Full record

ArticleFrontiers in neuroscience2021

Oxytocin-Trust Link in Oxytocin-Sensitive Participants and Those Without Autistic Traits.

Hirofumi Kurokawa, Yusuke Kinari, Hiroko Okudaira, Kiyotaka Tsubouchi, Yoshimichi Sai, Mitsuru Kikuchi, Haruhiro Higashida, Fumio Ohtake

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Neuroscience Needs to Test Both Statistical and Scientific Hypotheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Hirofumi KurokawaSchool of Economics and Management, University of Hyogo, Kobe, Japan.
Yusuke KinariHirao School of Management, Konan University, Nishinomiya, Japan.
Hiroko OkudairaDoshisha Business School, Doshisha University, Kyoto, Japan.
Kiyotaka TsubouchiDepartment of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan.
Yoshimichi SaiDepartment of Hospital Pharmacy, Kanazawa University, Kanazawa, Japan.
Mitsuru KikuchiDepartment of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Haruhiro HigashidaResearch Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.
Fumio OhtakeCenter for Infectious Disease Education and Research, Osaka University, Suita, Japan.
Kanazawa University · JPKanazawa University Hospital · JPDoshisha University · JPKonan University · JPOsaka University · JPUniversity of Hyogo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been numerous studies in which the biological role of oxytocin in trusting behavior has been investigated. However, a link between oxytocin and trust in humans was discovered only in one early study. We hypothesized that there is a large interindividual variation in oxytocin sensitivity, and that such variation is one reason for the doubt surrounding the role of oxytocin in trusting behavior. Here, in a double-blind, prospective, case-control study, we administered intranasal oxytocin to participants of trust and risk games. We measured salivary oxytocin concentration, relating it to the amount of money transferred among participants (a proxy for trust) and the autism-spectrum quotient (AQ). A one-sided Fisher's exact test was performed to detect differences between the oxytocin and placebo groups in the proportions of investors who transferred the maximum amount of money. We discovered a tendency for participants who received oxytocin to transfer higher amounts of money to co-participants than those who received a placebo (

Indexed as

humaninterindividual variationoxytocinsalivatrust

Identifiers

PMID34113232
PMCPMC8186783
OpenAlexW3164298814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.