Evidence map›Paper›PMID 34113103›Full record

ArticleInternational journal of nanomedicine2021

Cytotoxic Potential, Metabolic Profiling, and Liposomes of

Arafa Musa, Abeer H Elmaidomy, Ahmed M Sayed, Sami I Alzarea, Mohammad M Al-Sanea, Ehab M Mostafa, Omina Magdy Hendawy, Mohamed A Abdelgawad, Khayrya A Youssif, Hesham Refaat and 2 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cytotoxic and Antioxidant Potential ofMolecules (Basel, Switzerland) · 2023
    Article
  5. Plants (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Bioactive Phytochemicals ofAntioxidants (Basel, Switzerland) · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Arafa MusaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, 72341, Saudi Arabia.ORCID 0000-0003-0979-556X
Abeer H ElmaidomyDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.ORCID 0000-0002-4619-343X
Ahmed M SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef, 62513, Egypt.
Sami I AlzareaDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.
Mohammad M Al-SaneaPharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.ORCID 0000-0002-9820-4022
Ehab M MostafaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, 72341, Saudi Arabia.ORCID 0000-0001-8841-9786
Omina Magdy HendawyDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.
Mohamed A AbdelgawadPharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, Saudi Arabia.ORCID 0000-0001-9035-5638
Khayrya A YoussifDepartment of Pharmacognosy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
Hesham RefaatDepartment of Pharmaceutics, Faculty of Pharmacy, Deraya University, 7 Universities Zone, New Minia, 61111, Egypt.ORCID 0000-0002-1477-837X
Eman AlaaeldinDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSponge- METHODOLOGY: In the present study, the metabolomic profiling of

resultsThe identified metabolites were fit to diverse chemical classes, covering diterpenes, an indole alkaloid, sesterterpenoid, sterol, and methylherbipoline salt. Comprehensive in silico experiments predicted several compounds in the sponge-derived extract (eg, compounds DISCUSSION: Encapsulation of both the hydrophilic and the lipophilic components of the extract within the lipid-based nanovesicles enhanced the cellular uptake and accessibility of the entrapped cargo. This study introduces liposomal nano-vesicles as a promising approach to improve the therapeutic potential of sponge-derived extracts.

Indexed as

Computer SimulationMetabolomeAnimalsAntineoplastic AgentsApoptosisComplex MixturesHumansLiposomesNeoplasmsPoriferaTumor Cells, CulturedAntineoplastic AgentsComplex MixturesLiposomesantiproliferativeCoscinodermaLC-HRESIMSliposomesmetabolic profilingsponge

Identifiers

PMID34113103
PMCPMC8187037

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.