Trial reportClinical ophthalmology (Auckland, N.Z.)2021
The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma.
Trial report in Clinical ophthalmology (Auckland, N.Z.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Development of a machine learning model using systemic and ophthalmic parameters to detect sleep-disordered breathing in glaucoma patients.Japanese journal of ophthalmology · 2026Article
- Oxidative Stress in Glaucoma: From Pathogenic Mechanisms to Emerging Antioxidant Therapies.Antioxidants (Basel, Switzerland) · 2026Review
- Diet, Exercise, and Lifestyle in Glaucoma: Current Evidence and Future Perspectives.Nutrients · 2025Review
- Systemic oxidative stress levels and their associations with the risk of neovascular age-related macular degeneration and treatment response.International journal of retina and vitreous · 2025Article
- Comparison of the Effects of Tamarind Seed Extract (Tamarindus Indica L.) with Sertraline in Treating Premature Ejaculation: A Randomized Double-blind Trial : Tamarind vs. Sertraline in PE Treatment.Galen medical journal · 2025Article
- Exploring Glaucoma: From Pathogenesis to Emerging Diagnostic and Management Strategies.Journal of ophthalmology · 2025Review
- Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea.Antioxidants (Basel, Switzerland) · 2024Article
- Optic Nerve Neuroprotection in Glaucoma: A Narrative Review.Journal of clinical medicine · 2024Review
- Article
- Chronic Antioxidant Capacity Loss in Anterior Chamber Environment After Iridectomy.Translational vision science & technology · 2023Article
- DNA Damage and Repair in Eye Diseases.International journal of molecular sciences · 2023Review
- Association between dietary antioxidant indices and glaucoma in the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2023Article
- Sex differences in the association between systemic oxidative stress status and optic nerve head blood flow in normal-tension glaucoma.PloS one · 2023Article
- The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a review.Frontiers in physiology · 2023Review
- Clinical characteristics of glaucoma patients with various risk factors.BMC ophthalmology · 2022Article
- Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update.Nutrients · 2022Review
- A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma.Antioxidants (Basel, Switzerland) · 2021Review
- Crocetin: A Systematic Review.Frontiers in pharmacology · 2021Review
- The Potential of Lisosan G as a Possible Treatment for Glaucoma.Frontiers in pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and PATIENTS AND
methodsThis study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett's test.
resultsThe 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (
conclusionAn 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.