Evidence map›Paper›PMID 34112997›Full record

ArticleNature biomedical engineering2021

Adaptive adversarial neural networks for the analysis of lossy and domain-shifted datasets of medical images.

Manoj Kumar Kanakasabapathy, Prudhvi Thirumalaraju, Hemanth Kandula, Fenil Doshi, Anjali Devi Sivakumar, Deeksha Kartik, Raghav Gupta, Rohan Pooniwala, John A Branda, Athe M Tsibris and 4 more

Open access · greenAbstract read
In one paragraph

Article in Nature biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  15. Automation in ART: Paving the Way for the Future of Infertility Treatment.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Review
  16. Review
  17. Proceedings of the first world conference on AI in fertility.Journal of assisted reproduction and genetics · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Manoj Kumar Kanakasabapathy *Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Prudhvi Thirumalaraju *Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hemanth KandulaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Fenil DoshiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anjali Devi SivakumarDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Deeksha KartikDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Raghav GuptaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rohan PooniwalaDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John A BrandaDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Athe M TsibrisDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel R KuritzkesDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John C PetrozzaDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5864-2119
Charles L BormannDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hadi ShafieeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-2240-7648
Brigham and Women's Hospital · USHarvard University · US

Funding

Microchip for HBV testing using HIV-infected blood samplesR01AI138800 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2023
$3.1M
Sensitive and quantitative point-of-care viral load testing on paperR01AI118502 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2016 to 2020
$2.2M
A mobile health diagnostic device for HIV self-testingR61AI140489 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2021
$1.6M
NIAID NIH HHS R01 AI118502NIAID NIH HHS R01 AI138800NIAID NIH HHS R61 AI140489
6 · The paper itself

Abstract

In machine learning for image-based medical diagnostics, supervised convolutional neural networks are typically trained with large and expertly annotated datasets obtained using high-resolution imaging systems. Moreover, the network's performance can degrade substantially when applied to a dataset with a different distribution. Here, we show that adversarial learning can be used to develop high-performing networks trained on unannotated medical images of varying image quality. Specifically, we used low-quality images acquired using inexpensive portable optical systems to train networks for the evaluation of human embryos, the quantification of human sperm morphology and the diagnosis of malarial infections in the blood, and show that the networks performed well across different data distributions. We also show that adversarial learning can be used with unlabelled data from unseen domain-shifted datasets to adapt pretrained supervised networks to new distributions, even when data from the original distribution are not available. Adaptive adversarial networks may expand the use of validated neural-network models for the evaluation of data collected from multiple imaging systems of varying quality without compromising the knowledge stored in the network.

Indexed as

Neural Networks, ComputerSupervised Machine LearningDatasets as TopicEmbryo, MammalianFemaleHistocytochemistryHumansImage Interpretation, Computer-AssistedMalaria, FalciparumMaleMicroscopyPlasmodium falciparumSpermatozoaTime-Lapse Imaging

Identifiers

PMID34112997
PMCPMC8943917
OpenAlexW3169352206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.