Evidence map›Paper›PMID 34112936›Full record

ArticleCommunications biology2021

Lentiviral vector induces high-quality memory T cells via dendritic cells transduction.

Min Wen Ku, Pierre Authié, Fabien Nevo, Philippe Souque, Maryline Bourgine, Marta Romano, Pierre Charneau, Laleh Majlessi

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  4. Application of Orthoflavivirus Pseudovirus Technology in Antiviral Research.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Min Wen KuLaboratoire Commun Pasteur-TheraVectys, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-5342-1218
Pierre AuthiéLaboratoire Commun Pasteur-TheraVectys, Institut Pasteur, Paris, France.
Fabien NevoLaboratoire Commun Pasteur-TheraVectys, Institut Pasteur, Paris, France.
Philippe SouqueUnité de Virologie Moléculaire et Vaccinologie, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-3018-5603
Maryline BourgineLaboratoire Commun Pasteur-TheraVectys, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-8850-8073
Marta RomanoUnit In Vivo Models, Sciensano, Brussels, Belgium.ORCID http://orcid.org/0000-0001-8996-7899
Pierre CharneauLaboratoire Commun Pasteur-TheraVectys, Institut Pasteur, Paris, France. pierre.charneau@pasteur.fr.
Laleh MajlessiLaboratoire Commun Pasteur-TheraVectys, Institut Pasteur, Paris, France. laleh.majlessi@pasteur.fr.ORCID http://orcid.org/0000-0001-8648-4058
Institut Pasteur · FRSciensano (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a lentiviral vector harboring the human β2-microglobulin promoter, with predominant expression in immune cells and minimal proximal enhancers to improve vector safety. This lentiviral vector efficiently transduces major dendritic cell subsets in vivo. With a mycobacterial immunogen, we observed distinct functional signatures and memory phenotype in lentiviral vector- or Adenovirus type 5 (Ad5)-immunized mice, despite comparable antigen-specific CD8

Indexed as

Transduction, GeneticAnimalsbeta 2-MicroglobulinCD8-Positive T-LymphocytesDendritic CellsFemaleGenetic EngineeringGenetic VectorsHumansImmunity, CellularImmunologic MemoryLentivirusMiceMice, Inbred C57BLPromoter Regions, GeneticTransgenesbeta 2-Microglobulin

Identifiers

PMID34112936
PMCPMC8192903
OpenAlexW3169888196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.