ArticleCommunications biology2021
High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- A cortical output channel for perceptual categorization.Science advances · 2026Article
- Metabotropic Glutamatergic Signaling Adaptively Controls Trans-thalamic Communication.bioRxiv : the preprint server for biology · 2026Article
- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Layer 5 myelination gates corticothalamic coincidence detection.Nature communications · 2025Article
- Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.Nature communications · 2025Article
- Active and passive touch are differentially represented in the mouse somatosensory thalamus.PLoS biology · 2025Article
- Touch-evoked traveling waves establish a translaminar spacetime code.Science advances · 2025Article
- Transthalamic Pathways for Cortical Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- A dendritic mechanism for balancing synaptic flexibility and stability.Cell reports · 2024Article
- Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging.Cell reports · 2024Article
- Article
- Functional dynamics and selectivity of two parallel corticocortical pathways from motor cortex to layer 5 circuits in somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Network-neuron interactions underlying sensory responses of layer 5 pyramidal tract neurons in barrel cortex.PLoS computational biology · 2024Article
- Circuits in the motor cortex explain oscillatory responses to transcranial magnetic stimulation.Network neuroscience (Cambridge, Mass.) · 2024Article
- Holistic bursting cells store long-term memory in auditory cortex.Nature communications · 2023Article
- Article
- Highly branched and complementary distributions of layer 5 and layer 6 auditory corticofugal axons in mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Targeting operational regimes of interest in recurrent neural networks.PLoS computational biology · 2023Article
- Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits.Network neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. We find major differences across layers and cell-types. The temporal structure of spontaneous spiking contains high-frequency bursts (≥100 Hz) in all morphological cell-types but a significant increase upon whisker touch is restricted to layer L5 thick-tufted pyramids (L5tts) and thus provides a distinct neurophysiological signature. We find that whisker touch can also be decoded from L5tt bursting, but not from other cell-types. We observed high-frequency bursts in L5tts projecting to different subcortical regions, including thalamus, midbrain and brainstem. We conclude that bursts in L5tts allow accurate coding and decoding of exploratory whisker touch.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.