ArticleScientific reports2021
Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Gene Loss DB: a curated database for gene loss in mammals-the cetacean collection.Database : the journal of biological databases and curation · 2025Article
- Evolution of ion channels in cetaceans: a natural experiment in the tree of life.Scientific reports · 2024Article
- Interactions between avian viruses and skin in farm birds.Veterinary research · 2024Review
- Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life.Scientific reports · 2024Article
- Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes.Scientific reports · 2024Article
- Development-Associated Genes of the Epidermal Differentiation Complex (EDC).Journal of developmental biology · 2024Review
- Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis.iScience · 2023Article
- Article
- Heme Oxygenase-1 Is Upregulated during Differentiation of Keratinocytes but Its Expression Is Dispensable for Cornification of Murine Epidermis.Journal of developmental biology · 2023Article
- Differential Loss of OAS Genes Indicates Diversification of Antiviral Immunity in Mammals.Vaccines · 2023Article
- Genenames.org: the HGNC resources in 2023.Nucleic acids research · 2023Article
- Cetacean epidermal specialization: A review.Anatomia, histologia, embryologia · 2022Review
- Evolutionary diversification of epidermal barrier genes in amphibians.Scientific reports · 2022Article
- Comparative genomics reveals evolutionary loss of epiplakin in cetaceans.Scientific reports · 2022Article
- The Interactions of Small Proline-Rich Proteins with Late Cornified Envelope Proteins are Involved in the Pathogenesis of Psoriasis.Clinical, cosmetic and investigational dermatology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Major protein components of the mammalian skin barrier are encoded by genes clustered in the Epidermal Differentiation Complex (EDC). The skin of cetaceans, i.e. whales, porpoises and dolphins, differs histologically from that of terrestrial mammals. However, the genetic regulation of their epidermal barrier is only incompletely known. Here, we investigated the EDC of cetaceans by comparative genomics. We found that important epidermal cornification proteins, such as loricrin and involucrin are conserved and subtypes of small proline-rich proteins (SPRRs) are even expanded in numbers in cetaceans. By contrast, keratinocyte proline rich protein (KPRP), skin-specific protein 32 (XP32) and late-cornified envelope (LCE) genes with the notable exception of LCE7A have been lost in cetaceans. Genes encoding proline rich 9 (PRR9) and late cornified envelope like proline rich 1 (LELP1) have degenerated in subgroups of cetaceans. These data suggest that the evolution of an aquatic lifestyle was accompanied by amplification of SPRR genes and loss of specific other epidermal differentiation genes in the phylogenetic lineage leading to cetaceans.
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