ArticleScientific reports2021
Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Vitamin D as a Regulator of the Biological Clock-Implications for Circadian-Metabolic Dysregulation.International journal of molecular sciences · 2026Review
- The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis.Molecular psychiatry · 2026Article
- Deletion of Clock GeneClocks & sleep · 2026Article
- The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Deletion of Clock GeneClocks & sleep · 2025Article
- Review
- Beyond vision: effects of light on the circadian clock and mood-related behaviours.Npj biological timing and sleep · 2025Review
- The role of vitamin D in sleep regulation: mechanisms, clinical advances, and future directions.Frontiers in nutrition · 2025Review
- Knockdown ofFrontiers in physiology · 2025Article
- Molecular Rhythmicity in Glia: Importance for Brain Health and Relevance to Psychiatric Disease.Biological psychiatry · 2024Review
- Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice.Nature communications · 2024Article
- Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation.Communications biology · 2024Article
- ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice.Communications biology · 2023Article
- Deletion of the Circadian Clock GeneClocks & sleep · 2023Article
- Emotionally clocked out: cell-type specific regulation of mood and anxiety by the circadian clock system in the brain.Frontiers in molecular neuroscience · 2023Review
- Circadian Control of Glial Cell Homeodynamics.Journal of biological rhythms · 2022Article
- Mood phenotypes in rodent models with circadian disturbances.Neurobiology of sleep and circadian rhythms · 2022Review
- The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders.Frontiers in physiology · 2022Review
- The Circadian Molecular Machinery in CNS Cells: A Fine Tuner of Neuronal and Glial Activity With Space/Time Resolution.Frontiers in molecular neuroscience · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock regulates many biochemical and physiological pathways, and lack of clock genes, such as Period (Per) 2, affects not only circadian activity rhythms, but can also modulate feeding and mood-related behaviors. However, it is not known how cell-type specific expression of Per2 contributes to these behaviors. In this study, we find that Per2 in glial cells is important for balancing mood-related behaviors, without affecting circadian activity parameters. Genetic and adeno-associated virus-mediated deletion of Per2 in glial cells of mice leads to reduced despair and anxiety. This is paralleled by an increase of the GABA transporter 2 (Gat2/Slc6a13) and Dopamine receptor D3 (Drd3) mRNA, and a reduction of glutamate levels in the nucleus accumbens (NAc). Interestingly, neuronal Per2 knock-out also reduces despair, but does not influence anxiety. The change in mood-related behavior is not a result of a defective molecular clock, as glial Bmal1 deletion has no effect on neither despair nor anxiety. Exclusive deletion of Per2 in glia of the NAc reduced despair, but had no influence on anxiety. Our data provide strong evidence for an important role of glial Per2 in regulating mood-related behavior.
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