ArticleScientific reports2021
Structure-based redesigning of pentoxifylline analogs against selective phosphodiesterases to modulate sperm functional competence for assisted reproductive technologies.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Cryopreservation of Human Spermatozoa Using Penetrating Cryoprotectant-Free Vitrification Medium Exhibits an Altered Proteomic Profile Compared to the Conventional Rapid Freezing Method.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Efficacy and safety of oral pentoxifylline on semen parameters and reproductive hormones in idiopathic male infertility: a systematic review and meta-analysis.Translational andrology and urology · 2026Article
- Effects of Pentoxifylline Timing and Storage Temperature on Human Sperm Motility, Morphology, and Viability.Journal of family & reproductive health · 2025Article
- Potent and sustained enhancement of human sperm motility using novel cyclic AMP upregulators.Reproduction (Cambridge, England) · 2025Article
- Effects of pentoxifylline on mouse oocytes maturation and qualityIranian journal of basic medical sciences · 2025Article
- Oxidative Stress and Acrosomal Status of Human Spermatozoa Subjected to Hydrophobic Carbon Soot Treatments.Nanomaterials (Basel, Switzerland) · 2024Article
- Review
- Haploid Parthenogenetic Embryos Exhibit Unique Stress Response to pH, Osmotic and Oxidative Stress.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Human Sperm as an In Vitro Model to Assess the Efficacy of Antioxidant Supplements during Sperm Handling: A Narrative Review.Antioxidants (Basel, Switzerland) · 2023Review
- Cyclic Adenosine Monophosphate: A Central Player in Gamete Development and Fertilization, and Possible Target for Infertility Therapies.International journal of molecular sciences · 2022Article
- Hydrophobic soot nanoparticles as a non-cytotoxic motility activator of human spermatozoa.Nanoscale advances · 2022Article
- Sperm Selection for ICSI: Do We Have a Winner?Cells · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphodiesterase (PDE) inhibitors, such as pentoxifylline (PTX), are used as pharmacological agents to enhance sperm motility in assisted reproductive technology (ART), mainly to aid the selection of viable sperm in asthenozoospermic ejaculates and testicular spermatozoa, prior to intracytoplasmic sperm injection (ICSI). However, PTX is reported to induce premature acrosome reaction (AR) and, exert toxic effects on oocyte function and early embryo development. Additionally, in vitro binding studies as well as computational binding free energy (ΔG
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Registered trials
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