ArticleScientific reports2021
Influence of cardiovascular risk-factors on morphological changes of cerebral arteries in healthy adults across the life span.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
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- Vessels hiding in plain sight: quantifying brain vascular morphology in anatomical MR images using deep learning.bioRxiv : the preprint server for biology · 2025Article
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- Absence of fluctuation and inverted circadian rhythm of blood pressure increase the risk of cognitive dysfunction in cerebral small vessel disease patients.BMC neurology · 2023Article
- The effect of intensive statin therapy in non-symptomatic intracranial arteries: The STAMINA-MRI sub-study.Frontiers in neurology · 2023Article
- Modification of cerebrovascular morphologies during different stages of life.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Multimodal biological brain age prediction using magnetic resonance imaging and angiography with the identification of predictive regions.Human brain mapping · 2022Article
- Multimodal brain age prediction fusing morphometric and imaging data and association with cardiovascular risk factors.Frontiers in neurology · 2022Article
- Changing demography and the challenge of dementia in India.Nature reviews. Neurology · 2021Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral artery morphological alterations have been associated with several cerebrovascular and neurological diseases, whereas these structures are known to be highly variable among healthy individuals. To date, the knowledge about the influence of cardiovascular risk factors on the morphology of cerebral arteries is rather limited. The aim of this work was to investigate the impact of cardiovascular risk factors on the regional cerebroarterial radius and density. Time-of-Flight magnetic resonance angiography from 1722 healthy adults (21-82 years) were used to extract region-specific measurements describing the main cerebral artery morphology. Multivariate statistical analysis was conducted to quantify the impact of cardiovascular risk factors, including clinical and life behavioural factors, on each region-specific artery measurement. Increased age, blood pressure, and markers of obesity were significantly associated with decreased artery radius and density in most regions, with aging having the greatest impact. Additionally, females showed significantly higher artery density while males showed higher artery radius. Smoking and alcohol consumption did not show any significant association with the artery morphology. The results of this study improve the understanding of the impact of aging, clinical factors, and life behavioural factors on cerebrovascular morphology and can help to identify potential risk factors for cerebrovascular and neurological diseases.
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