Evidence map›Paper›PMID 34112818›Full record

ArticleScientific reports2021

Visual mapping of body image disturbance in anorexia nervosa reveals objective markers of illness severity.

Christina Ralph-Nearman, Armen C Arevian, Scott Moseman, Megan Sinik, Sheridan Chappelle, Jamie D Feusner, Sahib S Khalsa

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06332963 (Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06332963 narecruitingnot on this mapstarted 2024, after this paper: background citation

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2024 to 2028Enrolled102ConditionsAnorexia Nervosa, Body Image Disturbance, InteroceptionArmsFloatation-REST, IFT, EFT
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Examining Facets of Body Image Disturbance Across Anorexia Nervosa Illness and Recovery Stages.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Article
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Sensing the Self: The Role of the Insula and Interoception in Body Image.Current topics in behavioral neurosciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Christina Ralph-NearmanLaureate Institute for Brain Research (LIBR), Tulsa, OK, USA. ChristinaRalphNearman@gmail.com.
Armen C ArevianJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Scott MosemanLaureate Psychiatric Clinic and Hospital, Tulsa, OK, USA.
Megan SinikLaureate Institute for Brain Research (LIBR), Tulsa, OK, USA.
Sheridan ChappelleLaureate Institute for Brain Research (LIBR), Tulsa, OK, USA.
Jamie D FeusnerJane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Sahib S KhalsaLaureate Institute for Brain Research (LIBR), Tulsa, OK, USA. skhalsa@laureateinstitute.org.
Laureate Institute for Brain Research · USLaureate Psychiatric Clinic and Hospital · USUniversity of California, Los Angeles · USUniversity of Toronto · CAUniversity of Tulsa · US

Funding

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Maëlle Camille Marie Gueguen · 2017 to 2026
$23.7M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Neural mechanisms of perceptual abnormalities and their malleability in bodydysmorphic disorderR01MH121520 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2020 to 2025
$2.8M
Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
NIGMS NIH HHS P20 GM121312NIMH NIH HHS K23 MH112949NIMH NIH HHS R01 MH093676NIMH NIH HHS R01MH093676-02S1NIMH NIH HHS R01 MH105662NIMH NIH HHS R01 MH121520
6 · The paper itself

Abstract

Body image disturbance (BID) is a core feature of eating disorders, for which there are few objective markers. We examined the feasibility of a novel digital tool, "Somatomap", to index BID related to anorexia nervosa (AN) severity. Fifty-five AN inpatients and 55 healthy comparisons (HC) outlined their body concerns on a 2-Dimensional avatar. Next, they indicated sizes/shapes of body parts for their current and ideal body using sliders on a 3-Dimensional avatar. Physical measurements of corresponding body parts, in cm, were collected for reference. We evaluated regional differences in BID using proportional z-scores to generate statistical body maps, and multivariate analysis of covariance to assess perceptual discrepancies for current body, ideal body, and body dissatisfaction. The AN group demonstrated greater regional perceptual inaccuracy for their current body than HC, greater discrepancies between their current and ideal body, and higher body dissatisfaction than HCs. AN body concerns localized disproportionately to the chest and lower abdomen. The number of body concerns and perceptual inaccuracy for individual body parts was strongly associated with Eating Disorder Examination Questionnaire (Global EDE-Q) scores across both groups. Somatomap demonstrated feasibility to capture multidimensional aspects of BID. Several implicit measures were significantly associated with illness severity, suggesting potential utility for identifying objective BID markers.

Indexed as

AdolescentAdultAnorexia NervosaBiomarkersBody ImageFeeding and Eating DisordersFemaleHumansMaleSeverity of Illness IndexSurveys and QuestionnairesSymptom AssessmentYoung AdultBiomarkers

Identifiers

PMID34112818
PMCPMC8192536
OpenAlexW3167761454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.