Evidence map›Paper›PMID 34112724›Full record

ArticleLife science alliance2021

iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts.

Nicholas J Hess, Nikhila S Bharadwaj, Elizabeth A Bobeck, Courtney E McDougal, Shidong Ma, John-Demian Sauer, Amy W Hudson, Jenny E Gumperz

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Human CD4Immunology · 2024
    Article
  7. Human CD4iScience · 2024
    Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nicholas J HessDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0001-5720-9305
Nikhila S BharadwajDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-2854-2720
Elizabeth A BobeckDepartment of Animal Science, 201F Kildee Hall, Iowa State University, Ames, IA, USA.
Courtney E McDougalDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Shidong MaQLB Biotherapeutics, Inc., Boston, MA, USA.
John-Demian SauerDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0001-9367-794X
Amy W HudsonDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-9718-6910
Jenny E GumperzDepartment of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA jegumperz@wisc.edu.ORCID 0000-0003-1852-2192
University of Wisconsin–Madison · USIowa State University · USMedical College of Wisconsin · US

Funding

RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Mechanisms of iNKT cell anti-viral adjuvancyR01AI136500 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GUMPERZ, JENNY E. · 2018 to 2022
$1.9M
Modulating the Inflammasome to Generate Robust Cell Mediated ImmunityR01CA188034 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SAUER, JOHN-DEMIAN · 2015 to 2019
$1.7M
University of Wisconsin Transplant Reseach Training ProgramT32AI125231 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, DIXON B · 2016 to 2020
$1.2M
Understanding the impact of human NKT cells on hematopoiesisR21AI116007 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GUMPERZ, JENNY E. · 2015 to 2016
$421k
NCI NIH HHS R01 CA188034NHLBI NIH HHS T32 HL007899NIAID NIH HHS R01 AI136500NIAID NIH HHS R21 AI116007NIAID NIH HHS T32 AI055397NIAID NIH HHS T32 AI125231
6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells are a conserved population of innate T lymphocytes that interact with key antigen-presenting cells to modulate adaptive T-cell responses in ways that can either promote protective immunity, or limit pathological immune activation. Understanding the immunological networks engaged by iNKT cells to mediate these opposing functions is a key pre-requisite to effectively using iNKT cells for therapeutic applications. Using a human umbilical cord blood xenotransplantation model, we show here that co-transplanted allogeneic CD4

Indexed as

AnimalsAntigen-Presenting CellsCytokinesFemaleFetal BloodHumansImmunity, InnateImmunotherapyLymphocyte ActivationMiceMice, Inbred NODNatural Killer T-CellsTissue TransplantationTransplantation ImmunologyCytokines

Identifiers

PMID34112724
PMCPMC8200291
OpenAlexW3167762334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.