Evidence map›Paper›PMID 34112721›Full record

Trial reportArchives of disease in childhood. Fetal and neonatal edition2022

Comparison of two devices for automated oxygen control in preterm infants: a randomised crossover trial.

Hylke H Salverda, Sophie J E Cramer, Ruben S G M Witlox, Timothy J Gale, Peter A Dargaville, Steffen C Pauws, Arjan B Te Pas

4 registry-linked trialsOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03877198 naterminatednot on this map

A Randomized Cross-over Trial in the Effect of Automated Oxygen Control Devices on the Distribution of Oxygen Saturation in Preterm Infants

TypeinterventionalSponsorLeiden University Medical CenterRan2019 to 2020Enrolled15ConditionsPremature Infant, Respiratory Insufficiency, Hypoxia, HyperoxiaArmsAutomated oxygen control by the CLiO2 algorithm, Automated oxygen control by the Oxygenie algorithm
NCT05508308 nacompletednot on this map

Automated Oxygen Control for Preterm Infants On Continuous Positive Airway Pressure (CPAP): Phase 1/2 Trial In Southwest Nigeria

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2022 to 2023Enrolled49ConditionsNeonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure, Prematurity, Oxygen ToxicityArmsOxyMate, Manual oxygen control
NCT06622161 nacompletednot on this mapstarted 2024, after this paper: background citation

Automated Oxygen Control in Preterm Babies on Respiratory Support: A Randomized Cross Over Study

TypeinterventionalSponsorAga Khan University Hospital, PakistanRan2024 to 2025Enrolled26ConditionsPretermArmsautomated oxygen vs manual oxygen
NCT07622563 narecruitingnot on this mapstarted 2026, after this paper: background citation

Randomised Controlled Trial of Closed-loop Automated Oxygen Control in Preterm Infants Receiving Non-invasive Respiratory Support

TypeinterventionalSponsorKing's College Hospital NHS TrustRan2026 to 2027Enrolled76ConditionsInfant, Premature, Airway MorbidityArmsClosed loop automated oxygen control
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Automated oxygen delivery for preterm infants with respiratory dysfunction.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Time spent within the SpOBMJ open respiratory research · 2026
    Trial
  3. Trial
  4. Article
  5. Evolution of oxygen therapy in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2026
    Article
  6. Review
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hylke H SalverdaWillem-Alexander Children's Hospital, Department of Paediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands H.H.Salverda@lumc.nl.ORCID http://orcid.org/0000-0001-9355-5993
Sophie J E CramerWillem-Alexander Children's Hospital, Department of Paediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
Ruben S G M WitloxWillem-Alexander Children's Hospital, Department of Paediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
Timothy J GaleSchool of Engineering and ICT, University of Tasmania, Hobart, Tasmania, Australia.
Peter A DargavilleDepartment of Pediatrics, Royal Hobart Hospital, Hobart, Tasmania, Australia.
Steffen C PauwsWillem-Alexander Children's Hospital, Department of Paediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
Arjan B Te PasWillem-Alexander Children's Hospital, Department of Paediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
Leiden University Medical Center · NLUniversity of Tasmania · AUTilburg University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the effect of two different automated oxygen control devices on target range (TR) time and occurrence of hypoxaemic and hyperoxaemic episodes.

designRandomised cross-over study.

settingTertiary level neonatal unit in the Netherlands. PATIENTS: Preterm infants (n=15) born between 24+0 and 29+6 days of gestation, receiving invasive or non-invasive respiratory support with oxygen saturation (SpO

interventionsInspired oxygen concentration was titrated by the OxyGenie controller (SLE6000 ventilator) and the CLiO

main outcome measuresTime spent within set SpO

resultsTime spent within the SpO

conclusionsThe OxyGenie control algorithm was more effective in keeping the oxygen saturation within TR and preventing hyperoxaemia and equally effective in preventing hypoxaemia (SpO TRIAL REGISTRY NUMBER: NCT03877198.

Indexed as

Ventilators, MechanicalAlgorithmsCross-Over StudiesHumansHypoxiaInfant, NewbornInfant, PrematureOxygen SaturationRespiration, ArtificialRespiratory Distress Syndrome, Newbornneonatologytechnology

Identifiers

PMID34112721
PMCPMC8685610
OpenAlexW3168639700

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.