SynthesisArchives of disease in childhood. Fetal and neonatal edition2021
Neurodevelopmental outcome of patients with congenital gastrointestinal malformations: a systematic review and meta-analysis.
Synthesis in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Nutritional management of neonates who undergo major surgery for gastrointestinal disorders: a joint position paper of the Italian Society of Neonatology (SIN), the Italian Society of Pediatric Surgery (SICP), and the Italian Society of Pediatric Nutrition (SINUPE).Italian journal of pediatrics · 2026Guideline
- Post-discharge follow-up of congenital duodenal obstruction patients: a systematic review.Pediatric surgery international · 2023Pooled it
- Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Phenotyping trisomies 13 and 18 and CHARGE syndrome in fetal MRI-a proposed phenome-based, morphological disease severity score, and network medicine analysis.European radiology · 2026Article
- Neurodevelopmental assessment at 24 months in infants with esophageal atresia: A prospective cohort study.Journal of pediatric gastroenterology and nutrition · 2026Article
- Congenital Gastrointestinal Malformations in a Romanian Tertiary Centre (2020-2024): A Retrospective Cohort Study of Diagnosis, Distribution, and Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Findings in Chromosomal Microarray Analysis during Prenatal Diagnosis in High-Risk Individuals.Molecular syndromology · 2025Article
- Neurodevelopmental Outcomes in Newborns with Congenital Gastrointestinal Atresias.Children (Basel, Switzerland) · 2025Article
- General movement assessments in neonates born with congenital gastrointestinal anomalies: a single site, retrospective study.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Analysis of risk factors affecting psycho-behavioural development in children with short bowel syndrome.Pediatric surgery international · 2025Article
- Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Neurodevelopmental outcomes among children with congenital gastrointestinal anomalies using Korean National Health Insurance claims data.Scientific reports · 2024Article
- Article
- Nationwide Long-Term Growth and Developmental Outcomes of Infants for Congenital Anomalies in the Digestive System and Abdominal Wall Defects With Surgery in Korea.Journal of Korean medical science · 2023Article
- Article
- Article
- The impact of intestinal atresia on educational and mental health outcomes in school-aged children: A case-control cohort study.Pediatric surgery international · 2023Article
- Neurodevelopmental outcomes in individuals with VACTERL association. A population-based cohort study.PloS one · 2023Article
- Perioperative critical events and morbidity associated with anesthesia in early life: Subgroup analysis of United Kingdom participation in the NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE) prospective multicenter observational study.Paediatric anaesthesia · 2022Observational
- Colostomy Delays Cell Loss in the Brain and Improves Juvenile Survival in a Neonatal Rat Model of Hirschsprung's Disease.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimChildren with congenital gastrointestinal malformations may be at risk of neurodevelopmental impairment due to challenges to the developing brain, including perioperative haemodynamic changes, exposure to anaesthetics and postoperative inflammatory influences. This study aggregates existing evidence on neurodevelopmental outcome in these patients using meta-analysis.
methodPubMed, Embase and Web of Science were searched for peer-reviewed articles published until October 2019. Out of the 5316 unique articles that were identified, 47 studies met the inclusion criteria and were included. Standardised mean differences (Cohen's d) between cognitive, motor and language outcome of patients with congenital gastrointestinal malformations and normative data (39 studies) or the studies' control group (8 studies) were aggregated across studies using random-effects meta-analysis. The value of (clinical) moderators was studied using meta-regression and diagnostic subgroups were compared.
resultsThe 47 included studies encompassed 62 cohorts, representing 2312 patients. Children with congenital gastrointestinal malformations had small-sized cognitive impairment (d=-0.435, p<0.001; 95% CI -0.567 to -0.302), medium-sized motor impairment (d=-0.610, p<0.001; 95% CI -0.769 to -0.451) and medium-sized language impairment (d=-0.670, p<0.001; 95% CI -0.914 to -0.425). Patients with short bowel syndrome had worse motor outcome. Neurodevelopmental outcome was related to the number of surgeries and length of total hospital stay, while no relations were observed with gestational age, birth weight, age and sex.
interpretationThis study shows that children with congenital gastrointestinal malformations exhibit impairments in neurodevelopmental outcome, highlighting the need for routine screening of neurodevelopment during follow-up.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.