Evidence map›Paper›PMID 34112706›Full record

ArticleJournal of the American Society of Nephrology : JASN2021

Antibody and T Cell Response to SARS-CoV-2 Messenger RNA BNT162b2 Vaccine in Kidney Transplant Recipients and Hemodialysis Patients.

Dominique Bertrand, Mouad Hamzaoui, Veronique Lemée, Julie Lamulle, Mélanie Hanoy, Charlotte Laurent, Ludivine Lebourg, Isabelle Etienne, Mathilde Lemoine, Frank Le Roy and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 10 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 10 syntheses or guidelines pooled it, 186 citations in OpenAlex.

  1. Immunogenicity of COVID-19 vaccines in solid organ transplant recipients: a systematic review and meta-analysis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
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  3. Humoral and cellular response of COVID-19 vaccine among solid organ transplant recipients: A systematic review and meta-analysis.Transplant infectious disease : an official journal of the Transplantation Society · 2022
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  7. Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
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  11. Review
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  14. Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Dominique BertrandDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Mouad HamzaouiDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Veronique LeméeDepartment of Virology, Rouen University Hospital, Rouen, France.
Julie LamulleDepartment of Immunology and Biotherapies, Rouen University Hospital, Rouen, France.
Mélanie HanoyDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Charlotte LaurentDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Ludivine LebourgDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Isabelle EtienneDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Mathilde LemoineDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Frank Le RoyDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Dorian NezamDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.
Jean-Christophe PlantierDepartment of Virology, Rouen University Hospital, Rouen, France.
Olivier BoyerDepartment of Immunology and Biotherapies, Rouen University Hospital, Rouen, France.ORCID 0000-0002-7591-307
Dominique GuerrotDepartment of Nephrology, Transplantation and Hemodialysis, Rouen University Hospital, Rouen, France.ORCID 0000-0002-5953-5785
Sophie CandonDepartment of Immunology and Biotherapies, Rouen University Hospital, Rouen, France.
Université de Rouen Normandie · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in patients with ESKD, and vaccination is hoped to prevent infection.

methodsBetween January 18 and February 24, 2021, 225 kidney transplant recipients (KTRs) and 45 patients on hemodialysis (HDPs) received two injections of mRNA BNT162b2 vaccine. The postvaccinal humoral and cellular response was explored in the first 45 KTRs and ten HDPs.

resultsAfter the second dose, eight HDPs (88.9%) and eight KTRs (17.8%) developed antispike SARS-CoV-2 antibodies (

conclusionImmunization with BNT162b2 seems more efficient in HDPs, indicating that vaccination should be highly recommended in these patients awaiting a transplant. However, the current vaccinal strategy for KTRs may not provide effective protection against COVID-19 and will likely need to be improved.

Indexed as

Kidney TransplantationRenal DialysisAgedAntibodies, ViralBNT162 VaccineCohort StudiesCOVID-19COVID-19 VaccinesFemaleHumansImmunocompromised HostImmunosuppressive AgentsKidney Failure, ChronicMaleMiddle AgedPandemicsAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesImmunosuppressive AgentsRNA, MessengerSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2clinical immunologyCOVID-19hemodialysiskidney transplantation

Identifiers

PMID34112706
PMCPMC8729845
OpenAlexW3170537423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.