SynthesisBMJ open diabetes research & care2021
Lower extremity reamputation in people with diabetes: a systematic review and meta-analysis.
Synthesis in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05804565 (Randomised Controlled Trial Comparing Metatarsal Method of Transection Using Bone Cutters or Bone Saw on Outcomes After Ray Amputation), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomised Controlled Trial Comparing Metatarsal Method of Transection Using Bone Cutters or Bone Saw on Outcomes After Ray Amputation (MetaMet)
Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Preoperative BUN-to-Albumin Ratio Is Independently Associated with Major Reamputation After Distal Amputation in Diabetic Foot: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Article
- Diabetes-Associated Major Limb Amputation in Solomon Islands: A National, 5-Year Retrospective Study.World journal of surgery · 2025Article
- Impact of delayed amputation on clinical outcomes compared to that of early amputation in patients with blunt polytrauma.Scientific reports · 2025Article
- Below-Knee Amputations: A Qualitative Social Media Analysis of Perceived Outcomes.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- A behaviour change intervention promoting physical activity following dysvascular amputation: Protocol for a pilot study.PloS one · 2025Article
- Estimating Recent US Limb Loss Prevalence and Updating Future Projections.Archives of rehabilitation research and clinical translation · 2024Article
- Artificial intelligence's suggestions for level of amputation in diabetic foot ulcers are highly correlated with those of clinicians, only with exception of hindfoot amputations.International wound journal · 2024Article
- Conservative surgery in the management of diabetic foot complications (excluding Charcot). The role of the orthopedic surgeon.Journal of clinical orthopaedics and trauma · 2024Review
- Barriers and Facilitators to Cardiovascular Rehabilitation Programmes for People with Lower Limb Amputation: A Survey of Clinical Practice in Canada.Physiotherapy Canada. Physiotherapie Canada · 2024Article
- Commentary on Marzolini et al.Physiotherapy Canada. Physiotherapie Canada · 2024Article
- Association of remoteness and ethnicity with major amputation following minor amputation to treat diabetes-related foot disease.PloS one · 2024Article
- Comorbidity and risk factors of subsequent lower extremity amputation in patients diagnosed with diabetes in Saskatchewan, Canada.Chronic illness · 2023Article
- A Prospective Multicenter Study of a Weekly Application Regimen of Viable Human Amnion Membrane Allograft in the Management of Nonhealing Diabetic Foot Ulcers.Plastic and reconstructive surgery. Global open · 2023Article
- Incidence of Lower Extremity Amputation in Romania: A Nationwide 5-Year Cohort Study, 2015-2019.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- A single arm prospective feasibility study evaluating wound closure with a unique wearable device that provides intermittent plantar compression and offloading in the treatment of non-healing diabetic foot ulcers.International wound journal · 2023Article
- Epidemiology and Outcome of Nontraumatic Lower Limb Amputations.Medical journal of the Islamic Republic of Iran · 2023Article
- Adherence to General Diabetes and Foot Care Processes, with Prompt Referral, Are Associated with Amputation-Free Survival in People with Type 2 Diabetes and Foot Ulcers: A Scottish National Registry Analysis.Journal of diabetes research · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
In this study, we determined the reamputation-free survival to both limbs and to the contralateral limb only following an index amputation of any-level and assessed whether reamputation rates have changed over time. We completed a systematic search using PubMed and screened a total of 205 articles for data on reamputation rates. We reported qualitative characteristics of 56 studies that included data on reamputation rates and completed a meta-analysis on 22 of the studies which enrolled exclusively participants with diabetes. The random-effects meta-analysis fit a parametric survival distribution to the data for reamputations to both limbs and to the contralateral limb only. We assessed whether there was a temporal trend in the reamputation rate using the Mann-Kendall test. Incidence rates were high for reamputation to both limbs and to the contralateral limb only. At 1 year, the reamputation rate for all contralateral and ipsilateral reamputations was found to be 19% (IQR=5.1%-31.6%), and at 5 years, it was found to be 37.1% (IQR=27.0%-47.2%). The contralateral reamputation rate at 5 years was found to be 20.5% (IQR=13.3%-27.2%). We found no evidence of a trend in the reamputation rates over more than two decades of literature analyzed. The incidence of lower extremity reamputation is high among patients with diabetes who have undergone initial amputations secondary to diabetes, and rates of reamputation have not changed over at least two decades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.