ArticleThe Journal of thoracic and cardiovascular surgery2022
Characteristics and outcomes of patients with COVID-19 supported by extracorporeal membrane oxygenation: A retrospective multicenter study.
Article in The Journal of thoracic and cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Meta-analysis: percutaneous versus surgical VA-ECMO decannulation demonstrates no clear differences in most outcomes, with a signal toward lower infection.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026Pooled it
- Temporary mechanical circulatory support for COVID-19 patients: A systematic review of literature.Artificial organs · 2022Pooled it
- Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- Research Trends and Hotspots of Extracorporeal Membrane Oxygenation: A 10-Year Bibliometric Study and Visualization Analysis.Frontiers in medicine · 2021Pooled it
- The use of extracorporeal membrane oxygenation in COVID-19: a systematic review.Archives of medical science : AMS · 2025Review
- Article
- Relationship between the Pre-ECMO and ECMO Time and Survival of Severe COVID-19 Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Patient education and extracorporeal membrane oxygenation preferences of patients and providers in COVID care.PloS one · 2024Article
- Outcomes of patients with COVID-19 supported by venovenous extracorporeal membrane oxygenation for greater than 90 days.JTCVS open · 2023Article
- Article
- Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry.Critical care (London, England) · 2023Article
- Extracorporeal Membrane Oxygenation for Severe COVID-19 in Indian Scenario: A Single Center Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Clearance of blood stream infections in patients receiving extracorporeal membrane oxygenation: a retrospective single-center cohort study.BMC infectious diseases · 2023Article
- What is New in ECMO for COVID-19?Journal of cardiothoracic and vascular anesthesia · 2023Article
- Adhered ECMO cannula in COVID-19 related severe acute respiratory failure.Journal of cardiothoracic surgery · 2022Article
- Characteristics and Outcomes of COVID-19 Patients Supported by Venoarterial or Veno-Arterial-Venous Extracorporeal Membrane Oxygenation.Journal of cardiothoracic and vascular anesthesia · 2022Article
- Outcomes by cannulation methods for venovenous extracorporeal membrane oxygenation during COVID-19: A multicenter retrospective study.Artificial organs · 2022Article
- Key characteristics impacting survival of COVID-19 extracorporeal membrane oxygenation.Critical care (London, England) · 2022Article
- Commentary: Extracorporeal membrane oxygenation for Coronavirus Disease 2019: A step toward enlightenment or still flying blind?The Journal of thoracic and cardiovascular surgery · 2022Article
- Commentary: Rome wasn't built in a day: Learning from initial cohort studies for patients with coronavirus disease receiving extracorporeal membrane oxygenation.The Journal of thoracic and cardiovascular surgery · 2022Article
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Authors and funding
20 authors at 12 institutions in 2 countries.
Funding
Abstract
objectiveTo determine characteristics, outcomes, and clinical factors associated with death in patients with COVID-19 requiring extracorporeal membrane oxygenation (ECMO) support.
methodsA multicenter, retrospective cohort study was conducted. The cohort consisted of adult patients (18 years of age and older) requiring ECMO in the period from March 1, 2020, to September 30, 2020. The primary outcome was in-hospital mortality after ECMO initiation assessed with a time to event analysis at 90 days. Multivariable Cox proportional regression was used to determine factors associated with in-hospital mortality.
resultsOverall, 292 patients from 17 centers comprised the study cohort. Patients were 49 (interquartile range, 39-57) years old and 81 (28%) were female. At the end of the follow-up period, 19 (6%) patients were still receiving ECMO, 25 (9%) were discontinued from ECMO but remained hospitalized, 135 (46%) were discharged or transferred alive, and 113 (39%) died during the hospitalization. The cumulative in-hospital mortality at 90 days was 42% (95% confidence interval [CI], 36%-47%). Factors associated with in-hospital mortality were age (adjusted hazard ratio [aHR], 1.31; 95% CI, 1.06-1.61 per 10 years), renal dysfunction measured according to serum creatinine level (aHR, 1.21; 95% CI, 1.01-1.45), and cardiopulmonary resuscitation before ECMO placement (aHR, 1.87; 95% CI, 1.01-3.46).
conclusionsIn patients with severe COVID-19 necessitating ECMO support, in-hospital mortality occurred in fewer than half of the cases. ECMO might serve as a viable modality for terminally ill patients with refractory COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.