Evidence map›Paper›PMID 34112209›Full record

SynthesisWorld journal of emergency surgery : WJES2021

Accuracy of pre-hospital triage tools for major trauma: a systematic review with meta-analysis and net clinical benefit.

Silvia Gianola, Greta Castellini, Annalisa Biffi, Gloria Porcu, Andrea Fabbri, Maria Pia Ruggieri, Nino Stocchetti, Antonello Napoletano, Daniela Coclite, Daniela D'Angelo and 8 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in World journal of emergency surgery : WJES, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Substantial heterogeneity in trauma triage tool characteristic operationalization for identification of major trauma: a hybrid systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Pooled it
  2. Pooled it
  3. Impact of a comprehensive trauma pathway on workflow and clinical processes in a level III trauma center.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  4. Observational
  5. Interleukin-6 to identify mildly injured patients in the trauma resuscitation room - a clinical feasibility study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
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  15. Trauma team activation and triage of severely injured patients at one non-trauma-center hospital in Stockholm.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024
    Article
  16. Effectiveness of a two-tiered trauma team activation system at a level I trauma center.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Silvia GianolaUnit of Clinical Epidemiology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Greta CastelliniUnit of Clinical Epidemiology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. greta.castellini@grupposandonato.it.ORCID 0000-0002-3345-8187
Annalisa BiffiNational Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Gloria PorcuNational Centre for Healthcare Research and Pharmacoepidemiology, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy.
Andrea FabbriEmergency Department, AUSL della Romagna, Forlì, Italy.
Maria Pia RuggieriEmergency Department, AO San Giovanni Addolorata, Rome, Italy.
Nino StocchettiDepartment of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Antonello NapoletanoCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Daniela CocliteCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Daniela D'AngeloCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Alice Josephine FauciCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Laura IacorossiCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Roberto LatinaCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Katia SalomoneCentro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Shailvi GuptaAdams Cowley Shock Trauma Center, University of Maryland, Baltimora, MD, USA.
Primiano Iannone *Centro Eccellenza Clinica Qualità e Sicurezza delle Cure, Istituto Superiore di Sanità, Rome, Italy.
Osvaldo Chiara *Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Italian National Institute of Health guideline working group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe conducted a systematic review to evaluate and compare the accuracy of pre-hospital triage tools for major trauma in the context of the development of the Italian National Institute of Health guidelines on major trauma integrated management.

methodsPubMed, Embase, and CENTRAL were searched up to November 2019 for studies investigating pre-hospital triage tools. The ROC (receiver operating characteristics) curve and net clinical benefit for all selected triage tools were performed. Quality assessment was performed using the Quality Assessment of Diagnostic Accuracy Studies-2. Certainty of the evidence was judged with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

resultsWe found 15 observational studies of 13 triage tools for adults and 11 for children. In adults, according to the ROC curve and the net clinical benefit, the most reliable tool was the Northern French Alps Trauma System (TRENAU), adopting injury severity score (ISS) > 15 as reference (sensitivity (Sn), 0.92; specificity (Sp), 0.41; 1 study; sample size, 2572; high certainty of the evidence). When mortality as reference was considered, the pre-hospital triage tool with the best net clinical benefit trajectory was the New Trauma Score (NTS) < 18 (Sn, 0.82; Sp, 0.86; 1 study; sample size, 1001; moderate certainty of the evidence). In children, high variability among all triage tools for sensitivity and specificity was found.

conclusionSensitivity and specificity varied across all available pre-hospital trauma triage tools. TRENAU and NTS are the best accurate triage tools for adults, whereas in the pediatric area a large variability prevents any firm conclusion.

Indexed as

Emergency Medical ServicesHumansTriageWounds and InjuriesMajor traumaPre-hospital, AccuracySystematic reviewTriage

Identifiers

PMID34112209
PMCPMC8193906

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.