ArticleBMC infectious diseases2021
What is the burden of osteomyelitis in Germany? An analysis of inpatient data from 2008 through 2018.
Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of oral amoxicillin/clavulanic acid in the treatment of osteomyelitis: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Pooled it
- Combined High Hydrostatic Pressure and Additive Chemical Treatment Enhances Decontamination Efficiency in Bone Tissue Infected with Staphylococcal Biofilms.Microorganisms · 2026Article
- ISO-1 sustained-release hydrogel repairs infected bone defects by suppressing osteoblast pyroptosis and enhancing osteogenic differentiation via the MIF-CD74/PI3K/AKT signaling pathway.Materials today. Bio · 2026Article
- Outcomes and safety of antibiotic-loaded calcium sulfate beads in orthopaedics: A systematic review and meta-analysis.Journal of orthopaedics · 2026Review
- Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review.Pathogens (Basel, Switzerland) · 2026Review
- Emerging biomaterials for osteomyelitis treatment: from material design to anti-infection and tissue regeneration.Frontiers in cell and developmental biology · 2026Review
- Comparative evaluation of five nutrition-inflammation indices for predicting 28-day ICU mortality in critically ill patients with bone infections: a dual-cohort study with external validation and interpretable machine learning.Frontiers in nutrition · 2026Article
- Exploring the treatment of osteomyelitis based on nanozyme-based antibacterial strategies.Frontiers in medical technology · 2026Review
- Potential of organ-on-a-chip in advancing synthetic extracellular matrix technology for bone tissue engineering in dentistry (Review).Biomedical reports · 2026Review
- Staged Management of Bone Defects in Chronic Osteomyelitis and Nonunions Using Antibiotic-Loaded Calcium Sulphate-Hydroxyapatite: A Multicenter Retrospective Analysis of 101 Cases.Therapeutics and clinical risk management · 2026Article
- [Bacteriophages for the treatment of musculoskeletal infections-An overview of clinical use, open questions, and legal framework].Orthopadie (Heidelberg, Germany) · 2025Article
- [Osteomyelitis in adults].Radiologie (Heidelberg, Germany) · 2025Review
- Bacterial Osteomyelitis in the Lower Extremities: Analysis of Histology and MRI Findings in a Case-Control Pilot Study.Journal of clinical medicine · 2025Article
- Multicenter epidemiological distribution, pathogens, and drug-resistance characteristics of chronic osteomyelitis in Central China.Frontiers in public health · 2025Article
- Anti-inflammatory drugs as potential antimicrobial agents: a review.Frontiers in pharmacology · 2025Review
- Incidence of chronic osteomyelitis between 2016 and 2022 in a large, multicenter database in the United States.Journal of bone and joint infection · 2025Article
- The Efficacy of Calcium Sulfate/Hydroxyapatite (CaS/HA) Gentamicin in Osteomyelitis Treatment: A Case Series.Antibiotics (Basel, Switzerland) · 2024Article
- Susceptibility ofMolecules (Basel, Switzerland) · 2024Article
- Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis.Cellular and molecular life sciences : CMLS · 2024Article
- Osteomyelitis is associated with increased anti-inflammatory response and immune exhaustion.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe epidemiology of osteomyelitis in Germany is unknown, which makes it difficult to estimate future demands. Therefore, we aimed to analyse how the numbers of cases have developed over the last decade as a function of osteomyelitis subtype, age group, gender, and anatomical localization.
methodsOsteomyelitis rates were quantified based on annual ICD-10 diagnosis codes from German medical institutions between 2008 through 2018, provided by the Federal Statistical Office of Germany (Destatis).
resultsOverall osteomyelitis prevalence increased by 10.44% from 15.5 to 16.7 cases per 100,000 inhabitants between 2008 through 2018. Out of 11,340 cases in 2018, 47.6% were diagnosed as chronic, 33.2% as acute and 19.2% as unspecified osteomyelitis. Men were often affected than women with 63.4% of all cases compared to 36.6%. The largest proportion of patients comprised the age group 60-69 years (22.1%), followed by 70-79 years (21.7%). A trend towards more osteomyelitis diagnoses in older patients was observed. Lower extremities were most frequently infected with 73.8% of all cases in 2018 (+ 10.8% change).
conclusionsOsteomyelitis remains a serious problem for orthopedic and trauma surgery. Prevention methods and interdisciplinary approaches are strongly required.
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