Evidence map›Paper›PMID 34112082›Full record

ReviewThe journal of headache and pain2021

Migraine and neuroinflammation: the inflammasome perspective.

Oguzhan Kursun, Muge Yemisci, Arn M J M van den Maagdenberg, Hulya Karatas

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 7 pooled it
40.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 7 syntheses or guidelines pooled it, 319 citations in OpenAlex.

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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Oguzhan KursunDepartment of Neurology, City Hospital, Ankara, Turkey.ORCID https://orcid.org/0000-0003-3831-4227
Muge YemisciInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey.ORCID https://orcid.org/0000-0002-1528-1998
Arn M J M van den MaagdenbergDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.ORCID https://orcid.org/0000-0002-9310-5535
Hulya KaratasInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara, Turkey. hulyak@hacettepe.edu.tr.ORCID https://orcid.org/0000-0003-4838-6320
Hacettepe University · TRLeiden University · NLMemorial Ankara Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroinflammation has an important role in the pathophysiology of migraine, which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight findings of cortical spreading depolarization (CSD)-induced neuroinflammatory signaling in brain parenchyma from the inflammasome perspective. In addition, we discuss the limited data of the contribution of inflammasomes to other aspects of migraine pathophysiology, foremost the activation of the trigeminovascular system and thereby the generation of migraine pain. MAIN BODY: Inflammasomes are signaling multiprotein complexes and key components of the innate immune system. Their activation causes the production of inflammatory cytokines that can stimulate trigeminal neurons and are thus relevant to the generation of migraine pain. The contribution of inflammasome activation to pain signaling has attracted considerable attention in recent years. Nucleotide-binding domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) is the best characterized inflammasome and there is emerging evidence of its role in a variety of inflammatory pain conditions, including migraine. In this review, we discuss, from an inflammasome point of view, cortical spreading depolarization (CSD)-induced neuroinflammatory signaling in brain parenchyma, the connection with genetic factors that make the brain vulnerable to CSD, and the relation of the inflammasome with diseases that are co-morbid with migraine, including stroke, epilepsy, and the possible links with COVID-19 infection.

conclusionNeuroinflammatory pathways, specifically those involving inflammasome proteins, seem promising candidates as treatment targets, and perhaps even biomarkers, in migraine.

Indexed as

COVID-19Migraine DisordersHumansInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinSARS-CoV-2InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinComorbidityCortical spreading depolarizationInflammasomeMigraineMitochondrial DNANeuroinflammation

Identifiers

PMID34112082
PMCPMC8192049
OpenAlexW3167771504

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.