Evidence map›Paper›PMID 34112048›Full record

SynthesisPerfusion2022

Outcome of right ventricular assist device implantation following left ventricular assist device implantation: Systematic review and meta-analysis.

Gregory Reid, Constantin Mork, Brigita Gahl, Christian Appenzeller-Herzog, Ludwig K von Segesser, Friedrich Eckstein, Denis A Berdajs

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Perfusion, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  4. Review
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  7. HM6: greater than the sum of its parts?Interdisciplinary cardiovascular and thoracic surgery · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gregory ReidDepartment of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.
Constantin MorkDepartment of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.
Brigita GahlDepartment of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.
Christian Appenzeller-HerzogUniversity Medical Library, University Library of Basel, Basel, Switzerland.ORCID 0000-0001-7430-294X
Ludwig K von SegesserDepartment of Surgery and Anesthesiology Cardio-Vascular Research, University Hospital Lausanne, CHUV, Switzerland.ORCID 0000-0001-5400-9340
Friedrich EcksteinDepartment of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.
Denis A BerdajsDepartment of Cardiac Surgery, University Hospital Basel, Basel, Switzerland.ORCID 0000-0003-0478-903X
University Hospital of Basel · CHUniversity Hospital of Lausanne · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe main aim was a systematic evaluation of the current evidence on outcomes for patients undergoing right ventricular assist device (RVAD) implantation following left ventricular assist device (LVAD) implantation.

methodsThis systematic review was registered on PROSPERO (CRD42019130131). Reports evaluating in-hospital as well as follow-up outcome in LVAD and LVAD/RVAD implantation were identified through Ovid Medline, Web of Science and EMBASE. The primary endpoint was mortality at the hospital stay and at follow-up. Pooled incidence of defined endpoints was calculated by using random effects models.

resultsA total of 35 retrospective studies that included 3260 patients were analyzed. 30 days mortality was in favour of isolated LVAD implantation 6.74% (1.98-11.5%) versus 31.9% (19.78-44.02%) p = 0.001 in LVAD with temporary need for RVAD. During the hospital stay the incidence of major bleeding was 18.7% (18.2-19.4%) versus 40.0% (36.3-48.8%) and stroke rate was 5.6% (5.4-5.8%) versus 20.9% (16.8-28.3%) and was in favour of isolated LVAD implantation. Mortality reported at short-term as well at long-term was 19.66% (CI 15.73-23.59%) and 33.90% (CI 8.84-59.96%) in LVAD respectively versus 45.35% (CI 35.31-55.4%) p ⩽ 0.001 and 48.23% (CI 16.01-80.45%) p = 0.686 in LVAD/RVAD group respectively.

conclusionImplantation of a temporary RVAD is allied with a worse outcome during the primary hospitalization and at follow-up. Compared to isolated LVAD support, biventricular mechanical circulatory support leads to an elevated mortality and higher incidence of adverse events such as bleeding and stroke.

Indexed as

Heart-Assist DevicesHeart FailureVentricular Dysfunction, RightHemorrhageHumansRetrospective StudiesTreatment Outcomeleft ventricular assist deviceright heart failureright ventricular assist device

Identifiers

PMID34112048
PMCPMC9619248
OpenAlexW3166061616

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.