ArticleJournal of diabetes science and technology2022
Inspecting Insulin Products Using Water Proton NMR. I. Noninvasive vs Invasive Inspection.
Article in Journal of diabetes science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Rapid Parallel Magnetic Resonance Relaxometry on Multiwell Plates with a Benchtop Scanner.ACS omega · 2026Article
- Advancing Pharmaceutical Security: Noninvasive Detection of Falsified Vaccines and Drugs Using wNMR.Pharmaceutical research · 2025Article
- Decoupling Protein Concentration and Aggregate Content Using Diffusion and Water NMR.Analytical chemistry · 2024Article
- All vials are not the same: Potential role of vaccine quality in vaccine adverse reactions.Vaccine · 2021Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a clear need to transition from batch-level to vial/syringe/pen-level quality control of biologic drugs, such as insulin. This could be achieved only by noninvasive and quantitative inspection technologies that maintain the integrity of the drug product.
methodsFour insulin products for patient self-injection presented as prefilled pens have been noninvasively and quantitatively inspected using the water proton NMR technology. The inspection output is the water proton relaxation rate
resultsTen pens of each product were inspected.
conclusionsWater proton NMR can noninvasively and quantitatively inspect insulin pens.
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Registered trials
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