ArticleCirculation research2021
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation.
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Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
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Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Local calcium dynamics and signalling in cardiomyocytes.Nature reviews. Cardiology · 2026Review
- Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?The Journal of physiology · 2026Article
- Ca2+ signalling in cardiac muscle: the importance of balances.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Review
- APD restitution controls arrhythmia emergence in cardiac tissue with RyR2 dysfunction.The Journal of physiology · 2026Article
- Catecholaminergic polymorphic ventricular tachycardia: A narrative review of recent advances in genetics, mechanisms, diagnosis, and treatment.Asian heart journal · 2025Review
- Compromised repolarization reserve in a murine model of catecholaminergic polymorphic ventricular tachycardia caused by RyR2-R420Q mutation.Journal of molecular and cellular cardiology · 2025Article
- RYR2 Variants in Catecholaminergic Polymorphic Ventricular Tachycardia Patients: Insights From Protein Structure and Clinical Data.Circulation. Arrhythmia and electrophysiology · 2025Review
- Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia.Journal of molecular and cellular cardiology plus · 2025Article
- Pharmacological Enhancement of Small Conductance CaCirculation research · 2025Article
- Catecholaminergic Polymorphic Ventricular Tachycardia: Advancing From Molecular Insights to Preclinical Models.Journal of the American Heart Association · 2025Review
- Extracorporeal membrane oxygenation for catecholaminergic polymorphic ventricular tachycardia: a case report and literature review.BMC pediatrics · 2025Review
- Cryo-EM investigation of ryanodine receptor type 3.Nature communications · 2024Article
- Ryanodine receptor stabilization therapy suppresses CaJournal of molecular and cellular cardiology · 2024Article
- Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.Nature communications · 2024Article
- Dual effect of cardiac FKBP12.6 overexpression on excitation-contraction coupling and the incidence of ventricular arrhythmia depending on its expression level.Journal of molecular and cellular cardiology · 2024Article
- Can cardiomyocytes bypass the 'Ca2+-induced Ca2+-release' mechanism?Cardiovascular research · 2024Article
- Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies.Frontiers in molecular biosciences · 2024Article
- Arrhythmogenic mechanism of a novel ryanodine receptor mutation underlying sudden cardiac death.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Diversity of cells and signals in the cardiovascular system.The Journal of physiology · 2023Article
- Profiling the CaNature cardiovascular research · 2023Article
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Authors and funding
28 authors at 10 institutions in 8 countries.
Liheng Yin *Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Alexandra Zahradnikova *Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Riccardo Rizzetto *Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Simona BoncompagniCAST, Department of Neuroscience, Imaging and Clinical Sciences (DNICS), Medicine and Ageing Sciences (DMSI), University Gabriele d'Annunzio, Chieti, Italy (S.B., F.P.).
Camille Rabesahala de MeritensSwansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.).
Yadan ZhangSwansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.).
Pierre JoanneSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Elena Marqués-SuléSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Yuriana Aguilar-SánchezPhysiology and Biophysics, Rush University Medical Center, Chicago, IL, USA (Y.A.-S., J.R.-F.).
Miguel Fernández-TenorioPhysiology, University of Bern, Bern, Switzerland (M.F.-T., E.N.).
Olivier VillejoubertSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Linwei LiSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Yue Yi WangSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Philippe MateoSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Valérie NicolasIPSIT, 92296 Châtenay-Malabry, France (V.N.).
Pascale GerbaudSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
F Anthony LaiCollege of Medicine, Biomedical & Pharmaceutical Research Unit, QU Health, & Biomedical Research Centre, Qatar University, Doha, Qatar (F.A.L.).
Romain Perrier
Julio L ÁlvarezSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Ernst NiggliPhysiology, University of Bern, Bern, Switzerland (M.F.-T., E.N.).
Héctor H ValdiviaMedicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (H.H.V., C.R.V.).
Carmen R ValdiviaMedicine and Cardiovascular Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin (H.H.V., C.R.V.).
Josefina Ramos-Franco *Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA (Y.A.-S., J.R.-F.).
Esther Zorio *Cardiology Department and Unidad de Cardiopatías Familiares, Muerte Súbita y Mecanismos de Enfermedad (CaFaMuSMe), Hospital Universitario y Politécnico La Fe and Instituto de Investigación Sanitaria La Fe, Valencia, Spain (E.Z.).
Spyros Zissimopoulos *Swansea University Medical School, Institute of Life Science, Swansea, SA2 8PP, UK (C.R.d.M., Y.Z., S.Z.).
Feliciano Protasi *CAST, Department of Neuroscience, Imaging and Clinical Sciences (DNICS), Medicine and Ageing Sciences (DMSI), University Gabriele d'Annunzio, Chieti, Italy (S.B., F.P.).
Jean-Pierre Benitah *Signaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Ana M GómezSignaling and Cardiovascular Pathophysiology - UMR-S 1180, Inserm, Université Paris-Saclay 92296 Châtenay-Malabry, France (L.Y., A.Z., R.R., P.J., E.M.-S., O.V., L.L., Y.Y.W., P.M., P.G., R.P., J.L.A., J.-P.B., A.M.G.).
Inserm · FRSwansea University · GBRush University Medical Center · USUniversity of Bern · CHUniversity of Chieti-Pescara · ITUniversity of Wisconsin–Madison · USCentre for Biomedical Network Research on Rare Diseases · ESLaboratoire d'Énergétique Moléculaire et Macroscopique, Combustion · FRLaboratory Signaling and Cardiovascular Pathophysiology · FRQatar University · QA
Funding
Ryanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0MControl of IP3R-Mediated Calcium ReleaseR01GM111397 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, SUI RONG WAYNE, FILL, MICHAEL · 2015 to 2018
$1.6MBritish Heart Foundation FS/15/30/31494NHLBI NIH HHS R01 HL055438NIGMS NIH HHS R01 GM111397
Abstract
[Figure: see text].
Indexed as
Calcium SignalingAction PotentialsAnimalsBinding SitesCells, CulturedHEK293 CellsHumansMembrane ProteinsMiceMice, Inbred C57BLMutationMyocytes, CardiacPolymorphic Catecholaminergic Ventricular TachycardiaProtein BindingRyanodine Receptor Calcium Release ChannelTachycardia, VentricularjunctophilinMembrane ProteinsRyanodine Receptor Calcium Release ChannelRyR2 protein, humanaction potentialcalciumjunctophilinmutationryanodine receptorventricular tachycardia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.