ArticleCirculation2021
Nanoparticle Delivery of STAT3 Alleviates Pulmonary Hypertension in a Mouse Model of Alveolar Capillary Dysplasia.
Erratum issuedOpen access · bronzeAbstract read
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Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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34citing papers in PubMed
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34 citing papers in PubMed, 45 citations in OpenAlex.
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- Precision nanomedicine for pulmonary diseases: from molecular targeting to clinical translation.Signal transduction and targeted therapy · 2026Review
- Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway.Pulmonary circulation · 2026Review
- Emergence of fibrotic pericytes and their transcriptional regulation in pulmonary fibrosis.Nature communications · 2026Article
- Engineering function in lung biology: integrating imaging, regenerative constructs, and functional biodesign.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant.Clinics in perinatology · 2026Review
- FOXM1 inhibitor, RCM‑1, enhances venetoclax mediated apoptosis through downregulation of ATP2B4 in rhabdomyosarcoma.International journal of oncology · 2026Article
- FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury.Nature communications · 2026Article
- Endothelial Heterogeneity in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Pulmonary Fibrosis-Focusing on the Future: Aspen Lung Conference 2024 Summary.American journal of respiratory cell and molecular biology · 2025Article
- Nanoparticle-Based Delivery Systems for Synergistic Therapy in Lung Cancers.Bioengineering (Basel, Switzerland) · 2025Review
- CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- "Diamonds Are Forever": Novel Vascular Endothelial Growth Factor-Nanodiamond Therapy for the Treatment of Congenital Diaphragmatic Hernia.American journal of respiratory and critical care medicine · 2025Article
- Specialized Pulmonary Vascular Cells in Development and Disease.Annual review of physiology · 2025Review
- Transplantation of alveolar macrophages improves the efficacy of endothelial progenitor cell therapy in mouse model of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia.Nature communications · 2024Article
- FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4.EMBO molecular medicine · 2024Article
- TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue.Science translational medicine · 2024Article
- The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages.Frontiers in cell and developmental biology · 2024Article
Corrections and comments
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- Erratum issued
Authors and funding
18 authors at 2 institutions in 2 countries.
Fei SunCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Guolun WangCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Arun PradhanCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Kui XuCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Jose Gomez-ArroyoCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Yufang ZhangCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Gregory T KalinCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Zicheng DengCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Ronald J VagnozziDivision of Molecular Cardiovascular Biology, Heart Institute (R.J.V., A.J.Y., J.D.M.), Cincinnati Children's Hospital Medical Center, OH.
Hua HeDivision of Pulmonary Biology (G.T.K., H.H., T.V.K., J.D.M., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Andrew W DunnCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Yuhua WangDivision of Developmental Biology (Y.W., R.S.H., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Allen J YorkDivision of Molecular Cardiovascular Biology, Heart Institute (R.J.V., A.J.Y., J.D.M.), Cincinnati Children's Hospital Medical Center, OH.
Rashmi S HegdeDivision of Developmental Biology (Y.W., R.S.H., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Jason C WoodsDepartment of Pediatrics (R.S.H., J.C.W., T.V.K., J.S.M., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Tanya V KalinDivision of Pulmonary Biology (G.T.K., H.H., T.V.K., J.D.M., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Jeffery D MolkentinDivision of Pulmonary Biology (G.T.K., H.H., T.V.K., J.D.M., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Vladimir V KalinichenkoCenter for Lung Regenerative Medicine, Perinatal Institute (F.S., G.W., A.P., K.X., J.G.-A., Y.Z., G.T.K., Z.D., A.W.D., V.V.K.), Cincinnati Children's Hospital Medical Center, OH.
Cincinnati Children's Hospital Medical Center · USPerinatal Institute · GB
Funding
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3MTranscriptional Regulation of Endothelial Cells after Neonatal Lung InjuryR01HL141174 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2018 to 2026
$4.7MDevelopment of novel therapeutic approaches for treatment of Alveolar Capillary DysplasiaR01HL152973 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2021 to 2026
$3.6MA ROLE FOR EYA3 IN VASCULAR REMODELING AND PULMONARY ARTERIAL HYPERTENSIONR01HL152094 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI HEGDE, RASHMI S. · 2020 to 2023
$2.3MMolecular Mechanisms Regulated by FOXM1 in Chronic Lung RemodelingR01HL149631 · NHLBI · UNIVERSITY OF ARIZONA · PI KALINICHENKO, VLADIMIR · 2020 to 2022
$2.2MRole of lung endothelial cells during fibrotic lung remodeling.R01HL158659 · NHLBI · UNIVERSITY OF ARIZONA · PI KALIN, TANYA · 2021 to 2024
$2.2MTargeting Foxm1 in pulmonary fibrosisR01HL132849 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KALIN, TANYA · 2016 to 2019
$1.5MNHLBI NIH HHS R01 HL132849NHLBI NIH HHS R01 HL141174NHLBI NIH HHS R01 HL149631NHLBI NIH HHS R01 HL152094NHLBI NIH HHS R01 HL152973NHLBI NIH HHS R01 HL158659NHLBI NIH HHS T32 HL007752
Abstract
backgroundPulmonary hypertension (PH) is a common complication in patients with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with mutations in the
methodsWe used echocardiography, RV catheterization, immunostaining, and biochemical methods to examine lung and heart remodeling and RV output in
results
conclusionsNanoparticle therapies increasing neonatal pulmonary angiogenesis may be considered to prevent PH in ACDMPV.
Indexed as
Gene Transfer TechniquesNanoparticlesAirway RemodelingAnimalsBiomarkersDisease Models, AnimalDisease SusceptibilityDrug CarriersDrug Delivery SystemsEchocardiographyFibrosisForkhead Transcription FactorsGenetic TherapyHumansHypertension, PulmonaryHypertrophy, Right VentricularBiomarkersDrug CarriersForkhead Transcription FactorsFoxf1 protein, mouseSTAT3 Transcription Factoralveolar capillary dysplasiaFOXF1 protein, mousehypertension, pulmonarynanoparticlesSTAT3 transcription factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.