Evidence map›Paper›PMID 34111575›Full record

ArticleTransplantation and cellular therapy2021

Association of Inherited Chromosomally Integrated Human Herpesvirus 6 with Neurologic Symptoms and Management after Allogeneic Hematopoietic Cell Transplantation.

Madeleine R Heldman, Cassandra Job, Joyce Maalouf, Jessica Morris, Hu Xie, Chris Davis, Terry Stevens-Ayers, Meei-Li Huang, Keith R Jerome, Jesse R Fann and 3 more

Open access · greenAbstract read
In one paragraph

Article in Transplantation and cellular therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Madeleine R HeldmanFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington. Electronic address: mrh157@uw.edu.
Cassandra JobFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington.
Joyce MaaloufFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington.
Jessica MorrisFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington.
Hu XieFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington.
Chris DavisFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington.
Terry Stevens-AyersFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington.
Meei-Li HuangFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
Keith R JeromeFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.
Jesse R FannDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Danielle M ZerrFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington; Department of Pediatrics, University of Washington, Seattle, Washington.
Michael BoeckhFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.
Joshua A HillFred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington. Electronic address: jahill3@fredhutch.org.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

Training Program in Infectious Diseases in the Immunocompromised HostT32AI118690 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BOECKH, MICHAEL J · 2016 to 2025
$4.0M
NIAID NIH HHS T32 AI118690
6 · The paper itself

Abstract

Reactivation of human herpesvirus 6 (HHV-6) after allogeneic hematopoietic cell transplantation (HCT) is associated with neurologic complications, but the impact of donor and/or recipient inherited chromosomally integrated HHV-6 (iciHHV-6) on post-HCT central nervous system (CNS) symptoms and diagnostic and therapeutic interventions is not well understood. The aims of the present study were (1) to compare the cumulative incidence of CNS symptoms in the first 100 days following allogeneic HCT among patients with donor and/or recipient iciHHV-6 (iciHHV-6

Indexed as

Hematopoietic Stem Cell TransplantationHerpesvirus 6, HumanCohort StudiesHumansRetrospective StudiesTissue DonorsHematopoietic cell transplantationHuman herpesvirus 6ImmunocompromisedInherited chromosomally integrated human herpesvirus 6

Identifiers

PMID34111575
PMCPMC8403634
OpenAlexW3170021849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.