Evidence map›Paper›PMID 34111450›Full record

ReviewThe Journal of allergy and clinical immunology2021

The airway as a route of sensitization to peanut: An update to the dual allergen exposure hypothesis.

Michael D Kulis, Johanna M Smeekens, Robert M Immormino, Timothy P Moran

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. The Role of the Indoor Exposome in Food Allergy Development.Current allergy and asthma reports · 2026
    Review
  7. A novel ambient air sampler for detection of allergens and endotoxin.The journal of allergy and clinical immunology. Global · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Eating away at food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
  13. Review
  14. Article
  15. Allergens in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Oral mucosa effectively protects against peanut allergy in mice.The Journal of allergy and clinical immunology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael D KulisDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC; University of North Carolina Food Allergy Initiative, School of Medicine, University of North Carolina, Chapel Hill, NC. Electronic address: Mike.kulis@unc.edu.
Johanna M SmeekensDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC; University of North Carolina Food Allergy Initiative, School of Medicine, University of North Carolina, Chapel Hill, NC.
Robert M ImmorminoDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC.
Timothy P MoranDepartment of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC.
University of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
RESEARCH TRAINING IN ALLERGY AND CLINICAL IMMUNOLOGYT32AI007062 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David B. Peden, John W. Sleasman · 1985 to 2026
$6.1M
The role of neuropilin-2 in regulating environmental airways injuryK08ES029118 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORAN, TIMOTHY · 2019 to 2021
$635k
NIAID NIH HHS T32 AI007062NIEHS NIH HHS K08 ES029118NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Food allergies have increased at an alarming rate over the past 2 decades, indicating that environmental factors are driving disease progression. It has been postulated that sensitization to foods, in particular, peanut, occurs through impaired skin. Peanut allergens have been quantified in household dust and may be the culprit source. Indeed, T

Indexed as

AllergensAnimalsArachisHumansImmune TolerancePeanut HypersensitivityRespiratory SystemSkinAllergensairwaycutaneousdual allergen exposure hypothesisFood allergypeanut allergy

Identifiers

PMID34111450
PMCPMC8429226
OpenAlexW3172928157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.