Evidence map›Paper›PMID 34111216›Full record

ArticlePloS one2021

Direct cost of systemic arterial hypertension and its complications in the circulatory system from the perspective of the Brazilian public health system in 2019.

Daniel da Silva Pereira Curado, Dalila Fernandes Gomes, Thales Brendon Castano Silva, Paulo Henrique Ribeiro Fernandes Almeida, Noemia Urruth Leão Tavares, Camila Alves Areda, Everton Nunes da Silva

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. [Costs of pharmacological treatment in hypertension and type 2 diabetes mellitus].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Observational
  2. Article
  3. Integrative and complementary healthcare practices for hypertension: a summary of recommended clinical guidelines.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daniel da Silva Pereira CuradoGraduate Program in Public Health, University of Brasilia, Brasilia, Federal District, Brazil.ORCID 0000-0002-5965-4194
Dalila Fernandes GomesGraduate Program in Public Health, University of Brasilia, Brasilia, Federal District, Brazil.
Thales Brendon Castano SilvaFaculty of Pharmacy, Department of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil.
Paulo Henrique Ribeiro Fernandes AlmeidaFaculty of Pharmacy, Graduate Program in Medicines and Pharmaceutical Services, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Noemia Urruth Leão TavaresGraduate Program in Public Health, University of Brasilia, Brasilia, Federal District, Brazil.
Camila Alves AredaFaculty of Ceilandia, University of Brasilia, Brasilia, Federal District, Brazil.
Everton Nunes da SilvaGraduate Program in Public Health, University of Brasilia, Brasilia, Federal District, Brazil.ORCID 0000-0001-8747-4185
Universidade de Brasília · BRUniversidade Federal da Bahia · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSystemic arterial hypertension (SAH), a global public health problem and the primary risk factor for cardiovascular diseases, has a significant financial impact on health systems. In Brazil, the prevalence of SAH is 23.7%, which caused 203,000 deaths and 3.9 million DALYs in 2015.

objectiveTo estimate the cost of SAH and circulatory system diseases attributable to SAH from the perspective of the Brazilian public health system in 2019.

methodsA prevalence-based cost-of-illness was conducted using a top-down approach. The population attributable risk (PAR) was used to estimate the proportion of circulatory system diseases attributable to SAH. The direct medical costs were obtained from official Ministry of Health of Brazil records and literature parameters, including the three levels of care (primary, secondary, and tertiary). Deterministic univariate analyses were also conducted.

resultsThe total cost of SAH and the proportion of circulatory system diseases attributable to SAH was Int$ 581,135,374.73, varying between Int$ 501,553,022.21 and Int$ 776,183,338.06. In terms only of SAH costs at all healthcare levels (Int$ 493,776,445.89), 97.3% were incurred in primary care, especially for antihypertensive drugs provided free of charge by the Brazilian public health system (Int$ 363,888,540.14). Stroke accounted for the highest cost attributable to SAH and the third highest PAR, representing 47% of the total cost of circulatory diseases attributable to SAH. Prevalence was the parameter that most affected sensitivity analyses, accounting for 36% of all the cost variation.

conclusionOur results show that the main Brazilian strategy to combat SAH was implemented in primary care, namely access to free antihypertensive drugs and multiprofessional teams, acting jointly to promote care and prevent and control SAH.

Indexed as

Antihypertensive AgentsBrazilCardiovascular DiseasesCost of IllnessHealth Services AccessibilityHumansHypertensionPrevalencePrimary Health CarePublic HealthRisk AssessmentAntihypertensive Agents

Identifiers

PMID34111216
PMCPMC8191920
OpenAlexW3169291781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.