ArticlePloS one2021
Effect of number of medications and complexity of regimens on medication adherence and blood pressure management in hospitalized patients with hypertension.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Association between medication regimen complexity and glycemic control among patients with type 2 diabetes.Journal of the American Pharmacists Association : JAPhATrial
- Understanding the Gaps in Home Medication Safety: A Cross-Sectional Study of Knowledge, Attitudes, and Behavioral Determinants.Public health challenges · 2026Article
- Evaluation of medication regimen complexity and rehospitalization in older adults with chronic kidney disease: a retrospective cohort study.BMC geriatrics · 2026Article
- Medication Regimen Complexity and Patient-Reported Adherence: A Cross-Sectional Study in Internal Medicine Outpatients.Patient preference and adherence · 2026Article
- The Mediating Roles of Self-Efficacy, Resilience, and Social Support in the Relationship Between Clinical Factors and Adaptation to Chronic Disease.Journal of multidisciplinary healthcare · 2026Article
- Sentiment analysis in medication adherence: using ruled-based and artificial intelligence-driven algorithms to understand patient medication experiences.International journal of clinical pharmacy · 2025Article
- Article
- Is Satisfaction with the Medication Provisions of the Senior Citizens Act and Frequency of Senior Identification Card Use Associated with Medication Compliance among Hypertensive Patients in the Philippines?Acta medica Philippina · 2025Article
- The Correlation Between Medication Self-Management with Rational Medication Use Self-Efficacy and Medication Literacy in Patients with Stroke.Patient preference and adherence · 2025Article
- Statement on medication simplification in long-term care facilities by the Japanese Society of Geriatric Pharmacy: English translation of the Japanese article.Geriatrics & gerontology international · 2025Review
- Polypharmacy and medication regimen complexity in transfusion-dependent thalassaemia patients: a cross- sectional study.International journal of clinical pharmacy · 2024Observational
- Associations between Diabetes-Specific Medication Regimen Complexity and Cardiometabolic Outcomes among Underserved Non-Hispanic Black Adults Living with Type 2 Diabetes Mellitus.Pharmacy (Basel, Switzerland) · 2024Article
- Investigating the association between medication regimen complexity, medication adherence and treatment satisfaction among Malaysian older adult patients: a cross-sectional study.BMC geriatrics · 2024Article
- Review
- Patient Knowledge, Medication Adherence, and Influencing Factors: A Cross-Sectional Study among Hypertensive Patients in Greece.Healthcare (Basel, Switzerland) · 2024Article
- Medication Adherence of Older Adults with Hypertension: A Systematic Review.Patient preference and adherence · 2024Review
- Level of medication adherence and its determinants of cardiovascular disease patients attending at specialized teaching hospitals of Amhara regional state, Ethiopia: a multicenter cross-sectional study.Frontiers in pharmacology · 2024Article
- Utilizing Social Determinants of Health Model to Understand Barriers to Medication Adherence in Patients with Ischemic Stroke: A Systematic Review.Patient preference and adherence · 2023Review
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
- Associations of medication regimen complexity with medication adherence and clinical outcomes in patients with chronic obstructive pulmonary disease: a prospective study.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGood adherence of antihypertensives is recommended for the accomplishment of hypertension therapy. The number of medications and characteristics contributing to medication regimen complexity, such as dosage forms and dosing frequency, are known to influence medication adherence. However, the effect of medication regimen complexity on the therapeutic efficacy of medicines remains to be clarified. In the present study, we retrospectively investigated the effect of number of medications and medication regimen complexity on medication adherence and therapeutic efficacy in patients with hypertension.
methodsAccording to the inclusion and exclusion criteria, 1,057 patients, who were on medications including antihypertensives on admission at the Mie University Hospital between July 2018 and December 2018, were enrolled in this study. Poor blood pressure management was defined if the systolic or diastolic blood pressure were ≥140 mmHg or ≥ 90 mmHg. Medication regimen complexity was quantified using the medication regimen complexity index (MRCI) score.
resultsAmong 1,057 patients, 164 and 893 patients were categorized into poor and good adherence groups, respectively. The multivariate analyses revealed that age ≥ 71 years and oral MRCI score ≥ 19.5 but not number of oral medications were extracted as risk factors for poor medication adherence. Medication adherence and blood pressure management were poor in the group with oral MRCI score ≥ 19.5, regardless of the age. The rate of readmission was similar.
conclusionOur study is the first to demonstrate that medication regimen complexity rather than number of medications is closely related to medication adherence and blood pressure management. Hence, physicians and/or pharmacists should consider the complexity of medication regimens while modifying them.
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