ArticleCirculation research2021
Epidemiology and Genetics of Venous Thromboembolism and Chronic Venous Disease.
Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Endovenous laser ablation versus radiofrequency ablation in chronic venous insufficiency: a comparative meta-analysis of efficacy and safety.Frontiers in medicine · 2026Pooled it
- The 2023 Society for Vascular Surgery, American Venous Forum, and American Vein and Lymphatic Society clinical practice guidelines for the management of varicose veins of the lower extremities. Part II: Endorsed by the Society of Interventional Radiology and the Society for Vascular Medicine.Journal of vascular surgery. Venous and lymphatic disorders · 2024Guideline
- Early cardiac doppler findings and venous hemodynamic burden after combined superficial venous treatment for primary lower extremity varicose veins: an exploratory retrospective cohort study.Lasers in medical science · 2026Article
- Proteomic Biomarkers in VTE: From Discovery to Clinical Translation.Journal of clinical medicine · 2026Review
- Patterns of presentation of suspected and confirmed recurrent venous thromboembolism in patients with prior venous thromboembolism.Research and practice in thrombosis and haemostasis · 2026Observational
- Review
- Polygenic risk scores: Navigating the future of precision medicine through economic, ethical, and scientific advancements.iScience · 2026Review
- From venous congestion to placental hypoxia: the underappreciated role of chronic venous disease in impaired placenta development and pregnancy health.Frontiers in medicine · 2026Review
- An ethnographic study of sociocultural determinants and health system gaps in chronic venous disease in Calabria.Scientific reports · 2025Article
- Genome-wide association study-driven identification of thrombomodulin and factor V as the best biomarker combination for deep vein thrombosis.Genomics & informatics · 2025Article
- Cold hypersensitivity in the lower extremities: an underappreciated symptom in patients with varicose veins.Open heart · 2025Article
- Whole genome sequencing identifies pathogenic genetic variants in Han Chinese patients with familial venous thromboembolism.Communications biology · 2025Article
- Therapeutic applications of natural products in the management of venous diseases: a comprehensive review.Inflammopharmacology · 2025Review
- Article
- Evidence of Inflammatory Network Disruption in Chronic Venous Disease: An Analysis of Circulating Cytokines and Chemokines.Biomedicines · 2025Article
- Multimorbidity, comorbidity, frailty, and venous thromboembolism.Haematologica · 2024Review
- Transcatheter bicuspid venous valve prostheses: fluid mechanical performance testing of artificial nonwoven leaflets.Biomedical engineering online · 2024Article
- Decoding Pulmonary Embolism: Pathophysiology, Diagnosis, and Treatment.Biomedicines · 2024Review
- Research into New Molecular Mechanisms in Thrombotic Diseases Paves the Way for Innovative Therapeutic Approaches.International journal of molecular sciences · 2024Review
- Association between varicose veins and constitution of traditional Chinese medicine plus heart-failure-like symptoms.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Venous disease is a term that broadly covers both venous thromboembolic disease and chronic venous disease. The basic pathophysiology of venous thromboembolism and chronic venous disease differ as venous thromboembolism results from an imbalance of hemostasis and thrombosis while chronic venous disease occurs in the setting of tissue damage because of prolonged venous hypertension. Both diseases are common and account for significant mortality and morbidity, respectively, and collectively make up a large health care burden. Despite both diseases having well-characterized environmental components, it has been known for decades that family history is an important risk factor, implicating a genetic element to a patient's risk. Our understanding of the pathogenesis of these diseases has greatly benefited from an expansion of population genetic studies from pioneering familial studies to large genome-wide association studies; we now have multiple risk loci for each venous disease. In this review, we will highlight the current state of knowledge on the epidemiology and genetics of venous thromboembolism and chronic venous disease and directions for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.