Evidence map›Paper›PMID 34110822›Full record

ArticleJournal of natural products2021

Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities.

April L Risinger, Shayne D Hastings, Lin Du

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

April L RisingerDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, United States.ORCID 0000-0002-4363-3268
Shayne D HastingsDepartment of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, United States.
Lin DuDepartment of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma 73019-5251, United States.ORCID 0000-0001-8751-4482
The University of Texas Health Science Center at San Antonio · USUniversity of Oklahoma · US

Funding

Optimization of a novel class of microtubule stabilizersR01CA219948 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI RISINGER, APRIL L · 2018 to 2022
$1.7M
NCI NIH HHS R01 CA219948
6 · The paper itself

Abstract

The C-22,23-epoxy taccalonolides are microtubule stabilizers that bind covalently to β-tubulin with a high degree of specificity. We semisynthesized and performed biochemical and cellular evaluations on 20 taccalonolide analogues designed to improve target engagement. Most notably, modification of C-6 on the taccalonolide backbone with the C-13

Indexed as

HeLa CellsHumansMolecular Docking SimulationMolecular StructurePaclitaxelSteroidsStructure-Activity RelationshipTubulinTubulin ModulatorsPaclitaxelSteroidsTubulinTubulin Modulators

Identifiers

PMID34110822
PMCPMC8656239
OpenAlexW3169912768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.