Evidence map›Paper›PMID 34110786›Full record

ArticleACS infectious diseases2021

Antimicrobial Susceptibility Testing of Antimicrobial Peptides Requires New and Standardized Testing Structures.

Marita Meurer, Deborah A O'Neil, Emma Lovie, Laura Simpson, Marcelo D T Torres, Cesar de la Fuente-Nunez, Alfredo M Angeles-Boza, Christin Kleinsorgen, Derry K Mercer, Maren von Köckritz-Blickwede

Abstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marita MeurerDepartment of Biochemistry, University of Veterinary Medicine Hannover, Foundation, 30559 Hanover, Germany.
Deborah A O'NeilNovaBiotics Ltd, Aberdeen, AB23 8EW, United Kingdom.
Emma LovieNovaBiotics Ltd, Aberdeen, AB23 8EW, United Kingdom.
Laura SimpsonNovaBiotics Ltd, Aberdeen, AB23 8EW, United Kingdom.
Marcelo D T TorresMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Cesar de la Fuente-NunezMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Alfredo M Angeles-BozaDepartment of Chemistry, University of Connecticut, Storrs, Connecticut 06269-3060, United States.ORCID 0000-0002-5560-4405
Christin KleinsorgenCenter for E-Learning, Didactics and Educational Research (ZELDA), University of Veterinary Medicine Hannover, Foundation, 30559 Hanover, Germany.
Derry K MercerNovaBiotics Ltd, Aberdeen, AB23 8EW, United Kingdom.ORCID 0000-0001-8950-0076
Maren von Köckritz-BlickwedeDepartment of Biochemistry, University of Veterinary Medicine Hannover, Foundation, 30559 Hanover, Germany.ORCID 0000-0001-7712-9767

Funding

Combining chemical and computational tools for predictive models of microbiome communitiesR35GM138201 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DE LA FUENTE, CESAR · 2020 to 2024
$1.8M
NIGMS NIH HHS R35 GM138201
6 · The paper itself

Abstract

The need for optimized as well as standardized test systems of novel antimicrobial peptides (AMPs) was discussed by experts in the field at the International Meeting on Antimicrobial Peptides (IMAP) 2017 and the 2019 Gordon Research Conference (GRC) on Antimicrobial Peptides, and a survey related to this topic was circulated to participants to collate opinions. The survey included questions ranging from the relevance of susceptibility testing for understanding the mode of action of AMPs, to the importance of optimization and a degree of standardization of test methods and their clinical relevance. Based on the survey results, suggestions for future improvements in the research field are made.

Indexed as

Anti-Infective AgentsHumansPore Forming Cytotoxic ProteinsAnti-Infective AgentsPore Forming Cytotoxic Proteins

Identifiers

PMID34110786
PMCPMC8764967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.