Evidence map›Paper›PMID 34110566›Full record

ArticleCell biochemistry and biophysics2021

Bioflavonoid (Hesperidin) Restrains Protein Oxidation and Advanced Glycation End Product Formation by Targeting AGEs and Glycolytic Enzymes.

Mohd Shahnawaz Khan, Md Tabish Rehman, Mohamed A Ismael, Mohamed F AlAjmi, Ghaida I Alruwaished, Majed S Alokail, Mohammad Rashid Khan

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Article in Cell biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Phytochemical Characterisation and Bioactivity ofMolecules (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mohd Shahnawaz KhanProtein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. moskhan@ksu.edu.sa.ORCID http://orcid.org/0000-0002-4599-5924
Md Tabish RehmanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohamed A IsmaelProtein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mohamed F AlAjmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ghaida I AlruwaishedProtein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Majed S AlokailProtein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mohammad Rashid KhanDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
King Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-amylase (α-amylase) not long ago has acquire recognition as a possible drug target for the management of diabetes. Here, we have investigated the binding and enzyme activity of α-amylase by hesperidin; a naturally occurring flavanone having wide therapeutic potential. Hesperidin exerted an inhibitory influence on α-amylase activity with an IC

Indexed as

alpha-AmylasesGlycation End Products, AdvancedHesperidinMolecular Docking SimulationOxidation-ReductionBinding SitesFructosamineGlycolysisHumansHydrogen BondingProtein BindingThermodynamicsalpha-AmylasesFructosamineGlycation End Products, AdvancedHesperidinAmylaseDockingHesperidinNon-enzymatic glycationProtein oxidation

Identifiers

PMID34110566
OpenAlexW3167561829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.