Evidence map›Paper›PMID 34110481›Full record

ArticleArchives of microbiology2021

Optimization of (-)-cubebin biotransformation to (-)-hinokinin by the marine fungus Absidia coerulea 3A9.

Jonathan Messias de Souza, Mario Ferreira Conceição Santos, Rita Cassia Nascimento Pedroso, Leticia Pereira Pimenta, Kátia Aparecida Siqueira, Marcos Antonio Soares, Gustavo Muniz Dias, Rosemeire Cristina Linhari Rodrigues Pietro, Henrique Pereira Ramos, Marcio Luis Andrade Silva and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Marine-derived fungi as biocatalysts.Frontiers in microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jonathan Messias de Souza *Center for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0002-6525-1738
Mario Ferreira Conceição Santos *Center for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0003-1981-834X
Rita Cassia Nascimento PedrosoCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0001-7169-7720
Leticia Pereira PimentaCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0003-0074-3034
Kátia Aparecida SiqueiraDepartment of Botany and Ecology, Biosciences Institute, Federal University of Mato Grosso, Cuiabá, MT, 78060-900, Brazil.ORCID http://orcid.org/0000-0002-4765-0487
Marcos Antonio SoaresDepartment of Botany and Ecology, Biosciences Institute, Federal University of Mato Grosso, Cuiabá, MT, 78060-900, Brazil.ORCID http://orcid.org/0000-0002-8938-3188
Gustavo Muniz DiasCenter for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, SP, 09606-070, Brazil.ORCID http://orcid.org/0000-0003-2180-6399
Rosemeire Cristina Linhari Rodrigues PietroDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, University Estadual Paulista, Araraquara, SP, 14800-903, Brazil.ORCID http://orcid.org/0000-0001-7859-8127
Henrique Pereira RamosCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0001-6629-3641
Marcio Luis Andrade SilvaCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0002-9442-4757
Patricia Mendonça PaulettiCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0003-1831-0050
Rodrigo Cassio Sola VenezianiCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0001-7057-9706
Sérgio Ricardo AmbrósioCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil.ORCID http://orcid.org/0000-0001-5032-3930
Glaucia Hollaender BraunCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil. glaubraun@yahoo.com.br.ORCID http://orcid.org/0000-0002-1677-5332
Ana Helena JanuárioCenter for Research in Exact and Technological Sciences, University of Franca, Franca, SP, 14404-600, Brazil. ana.januario@unifran.edu.br.ORCID http://orcid.org/0000-0002-3815-6903

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302340/2018-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 23038.009588/2013-68 CSF-PVEs 27/2014Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/19184-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/14261-1
6 · The paper itself

Abstract

The genus Absidia is widely used in the biotransformation of different classes of natural products. This study evaluates the ability of the Absidia coerulea 3A9 marine derived strain isolated from the ascidian Distaplia stilyfera to perform biotransformations by conducting assays with (-)-cubebin, as substrate. The experiment was optimized using the experimental design proposed by Plackett-Burman for seven factors and eight experiments, to establish the biotransformation conditions that would allow maximum production of biotransformed dibenzylbutyrolactone (-)-hinokinin. An analytical method based on Reverse-Phase-High Performance Liquid Chromatography (RP-HPLC) was developed to quantify the fungal biotransformation product. The factor that influenced the (-)-hinokinin peak area the most positively was the percentage of seawater (%seawater) given that its %relative standard deviation (%RSD) showed a 32.92% deviation from the real value.

Indexed as

AbsidiaBenzodioxolesLignans4-ButyrolactoneAquatic OrganismsBiotransformationSeawater4-ButyrolactoneBenzodioxolescubebinhinokininLignansAbsidia coeruleaAscidianDistaplia stilyfera(–)-hinokininMarine fungiPlackett–Burman

Identifiers

PMID34110481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.