ArticleArchives of microbiology2021
Evaluation of the antioxidant, antibacterial, and antibiofilm activity of the sesquiterpene nerolidol.
Article in Archives of microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Current State of Knowledge Regarding WHO High Priority Pathogens-Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- The estrogen-progestogen-oxidative stress network in uterine fibroids: mechanistic insights and therapeutic opportunities.Redox report : communications in free radical research · 2026Review
- Review
- Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026Review
- Diverse Sesquiterpenoids With Antidiabetic Potency From the Fruits of Alpinia oxyphylla.Chemistry & biodiversity · 2026Article
- Fabrication and Characterization of Nerolidol-Based Invasomes: Loading, Stability and Antimicrobial Applications.Pharmaceutics · 2026Article
- Impact of Dry and Rainy Seasons on the Chemical Profile and Antioxidant Activity ofMolecules (Basel, Switzerland) · 2026Article
- Synergistic antimicrobial potential of Cinnamomum triplinerve essential oils combined with polymyxin B against multidrug-resistant Klebsiella pneumoniae.Scientific reports · 2026Article
- Article
- Dual Action of Ivy and Strawberry Essential Oils: Induction ofInternational journal of molecular sciences · 2025Article
- Characterization of Nerolidol Synthase (VsNES1) fromPlants (Basel, Switzerland) · 2025Article
- Nerolidol-loaded beta-cyclodextrin nanoparticles modulate Nrf-2/Keap1/NF-κB signaling to inhibit DMBA-induced mammary carcinogenesis in Sprague-Dawley rats.Medical oncology (Northwood, London, England) · 2025Article
- Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections.Chemistry & biodiversity · 2025Article
- Chemical Composition and Biological Activities of the Essential Oils from Different Parts ofMolecules (Basel, Switzerland) · 2025Article
- Food Chemistry and Bioactive Compounds in Relation to Health.Molecules (Basel, Switzerland) · 2025Article
- Review
- Nerolidol/hydroxypropyl-Food chemistry: X · 2025Article
- On the Path to a Sustainable Diet: Native Brazilian Fruits of the Caryocar spp. (Pequi and Piquiá) and Potential Health Benefits in Chronic Kidney Disease.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Review
- Harnessing Plant-Derived Terpenoids for Novel Approaches in Combating Bacterial and Parasite Infections in Veterinary and Agricultural Settings.Current microbiology · 2025Review
- Development and Evaluation of the Antibacterial Properties of an Experimental Herbal Gel Against Cariogenic Bacteria.Clinical and experimental dental research · 2025Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to evaluate the antioxidant, antibacterial, and antibiofilm activities of nerolidol. The antioxidant activity of nerolidol was determined using the total antioxidant activity method. Antibacterial activity was performed using the microdilution method to determine the minimum inhibitory concentration (MIC) against seven standard strains of the ATCC and four bacterial clinical isolates with a resistance profile, following the Clinical and Laboratory Standards Institute (CLSI). The antibiofilm activity of nerolidol was performed using the crystal violet method. The results of the antioxidant test revealed a total antioxidant activity of 93.94%. Nerolidol inhibited the growth of Staphylococcus aureus (MIC = 1 mg/mL), Streptococcus mutans (MIC = 4 mg/mL), Pseudomonas aeruginosa (MIC = 0.5 mg/mL), and Klebsiella pneumoniae (MIC = 0.5 mg/mL). For clinical isolates, nerolidol showed an inhibitory potential against multidrug-resistant P. aeruginosa, K. pneumoniae carbapenemase (MIC = 0.5 mg/mL), methicillin-susceptible S. aureus (MIC = 2 mg/mL), and methicillin-resistant S. aureus (MIC = 2 mg/mL). Nerolidol showed similar antibacterial activity against ATCC strains and hospital clinical isolates with resistance profile, suggesting that even though these strains are resistant to antibiotics, they are still sensitive to nerolidol. Nerolidol exerted a dose-dependent effect on the inhibition of biofilm formation, even at subinhibitory concentrations. Nerolidol inhibited bacterial biofilms of ATCC strains at a rate ranging from 51 to 98%, at concentrations ranging from 0.5 to 4 mg/mL. For clinical bacterial isolates, biofilm inhibition ranged from 6 to 60%. Therefore, the present study showed the antioxidant, antibacterial, and antibiofilm properties of nerolidol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.