ArticleAccounts of chemical research2021
Seeking Illumination: The Path to Chemiluminescent 1,2-Dioxetanes for Quantitative Measurements and
Article in Accounts of chemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Recent advances in chemiluminescence probes for Tumor microenvironment with applications in cancer diagnosis and therapy.Pharmaceutical science advances · 2026Review
- Endogenous near-infrared chemiluminescent manganese ion-driven porphyrin supramolecular platform for the theranostics of thrombosis and ischemic stroke.RSC advances · 2026Article
- A Metalloporphyrin Nanosystem Enables Non-Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Organic Afterglow Materials for Tumor Diagnosis and Therapy.Biosensors · 2025Review
- A silicon rhodamine 1,2-dioxetane chemiluminophore forOrganic & biomolecular chemistry · 2025Article
- A Bioluminescent Probe for HACS bio & med chem Au · 2025Article
- Enzymatic Activity Profiling Using an Ultrasensitive Array of Chemiluminescent Probes for Bacterial Classification and Characterization.Journal of the American Chemical Society · 2024Article
- The Role of Cuproptosis Key Factor FDX1 in Gastric Cancer.Current pharmaceutical biotechnology · 2024Article
- Recent Progress of Activity-Based Fluorescent Probes for Imaging Leucine Aminopeptidase.Biosensors · 2023Review
- The Molecular Basis of Organic Chemiluminescence.Biosensors · 2023Review
- Design and synthesis of a small molecular NIR-II chemiluminescence probe for in vivoProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Oxygen-Sensing Chemiluminescent Iridium(III) 1,2-Dioxetanes: Unusual Coordination and Activity.Analysis & sensing · 2023Article
- Kinetics-Based Quantification of Peroxynitrite Using the Oxidative Decarbonylation of Isatin.Analytical chemistry · 2022Article
- Organic persistent luminescence imaging for biomedical applications.Materials today. Bio · 2022Article
- Ultrasensitive chemiluminescent neuraminidase probe for rapid screening and identification of small-molecules with antiviral activity against influenza A virus in mammalian cells.Chemical science · 2022Article
- Recent advances in optical imaging through deep tissue: imaging probes and techniques.Biomaterials research · 2022Review
- Chemiluminescence in Combination with Organic Photosensitizers: Beyond the Light Penetration Depth Limit of Photodynamic Therapy.International journal of molecular sciences · 2022Review
- Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection.Current opinion in chemical biology · 2022Review
- Chemiluminescent 1,2-Dioxetane Iridium Complexes for Near-Infrared Oxygen Sensing.Angewandte Chemie (International ed. in English) · 2022Article
- A highly selective and sensitive chemiluminescent probe for leucine aminopeptidase detectionChemical science · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chemiluminescence is a fascinating phenomenon that evolved in nature and has been harnessed by chemists in diverse ways to improve life. This Account tells the story of our research group's efforts to formulate and manifest spiroadamantane 1,2-dioxetanes with triggerable chemiluminescence for imaging and monitoring important reactive analytes in living cells, animals, and human clinical samples. Analytes like reactive sulfur, oxygen and nitrogen species, as well as pH and hypoxia can be indicators of cellular function or dysfunction and are often implicated in the causes and effects of disease. We begin with a foundation in binding-based and activity-based fluorescence imaging that has provided transformative tools for understanding biological systems. The intense light sources required for fluorescence excitation, however, introduce autofluorescence and light scattering that reduces sensitivity and complicates
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.