Evidence map›Paper›PMID 34110129›Full record

ArticleBiochemistry2021

Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and

Jimin Wang, Krystle Reiss, Yuanjun Shi, Elias Lolis, George P Lisi, Victor S Batista

Abstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Design, Synthesis and Biological Exploration of NovelInternational journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Remdesivir: Quo vadis?Biochemical pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jimin WangDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, United States.ORCID 0000-0002-4504-8038
Krystle ReissDepartment of Chemistry, Yale University, New Haven, Connecticut 06511-8499, United States.
Yuanjun ShiDepartment of Chemistry, Yale University, New Haven, Connecticut 06511-8499, United States.
Elias LolisDepartment of Pharmacology, Yale University, New Haven, Connecticut 06520-8066, United States.ORCID 0000-0002-7902-7868
George P LisiDepartment of Molecular and Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, United States.
Victor S BatistaDepartment of Chemistry, Yale University, New Haven, Connecticut 06511-8499, United States.ORCID 0000-0002-3262-1237

Funding

Computational and Biochemical Studies of Temperature Effects on Allostery in the Imidazole Glycerol Phosphate Synthase (IGPS) from T. maritimaR01GM106121 · NIGMS · YALE UNIVERSITY · PI BATISTA, VICTOR S, LORIA, JOSEPH P · 2014 to 2021
$2.3M
NIGMS NIH HHS R01 GM106121
6 · The paper itself

Abstract

Remdesivir is an antiviral drug initially designed against the

Indexed as

Adenosine MonophosphateAlanineAntiviral AgentsBase PairingCoronavirus RNA-Dependent RNA PolymeraseEbolavirusEnzyme InhibitorsModels, MolecularProtein BiosynthesisRNARNA, MessengerRNA, ViralSARS-CoV-2Virus ReplicationAdenosine MonophosphateAlanineAntiviral AgentsCoronavirus RNA-Dependent RNA PolymeraseEnzyme InhibitorsNSP12 protein, SARS-CoV-2remdesivirRNARNA, MessengerRNA primersRNA, Viral

Identifiers

PMID34110129
PMCPMC8204756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.