Evidence map›Paper›PMID 34110106›Full record

ArticleCancer reports (Hoboken, N.J.)2022

Patient-reported pain severity and health-related quality of life in patients with multiple myeloma in real world clinical practice.

Heinz Ludwig, Abigail Lucy Bailey, Andrea Marongiu, Keerun Khela, Gary Milligan, Katherine Brewer Carlson, Alex Rider, Anouchka Seesaghur

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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  7. Perioperative considerations for patients with multiple myeloma.European journal of anaesthesiology and intensive care · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Heinz LudwigMedical Department Center for Oncology, Hematology and Palliative Medicine, Wilhelminen Cancer Research Institute, Vienna, Austria.
Abigail Lucy BaileyOncology, Adelphi Real World, Adelphi Mill, Bollington, UK.ORCID 0000-0002-0238-6723
Andrea MarongiuCentre for Observational Research, Amgen Ltd, Uxbridge, UK.
Keerun KhelaOncology, Adelphi Real World, Adelphi Mill, Bollington, UK.
Gary MilliganOncology, Adelphi Real World, Adelphi Mill, Bollington, UK.
Katherine Brewer CarlsonCenter for Observational Research, Amgen Inc, Thousand Oaks, California, USA.
Alex RiderOncology, Adelphi Real World, Adelphi Mill, Bollington, UK.
Anouchka SeesaghurCentre for Observational Research, Amgen Ltd, Uxbridge, UK.
Adelphi Group (United Kingdom) · GBAmgen (United Kingdom) · GBAmgen (United States) · USComprehensive Cancer Center Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between patient self-reported pain severity and health-related quality-of-life (HRQoL) is poorly understood.

aimsThis real-world study of symptomatic multiple myeloma (MM) patients sought to determine how pain severity from a single question asked during routine clinical consultation was associated with HRQoL. METHODS AND

resultsPoint-in-time data on HRQoL of 330 patients with MM (median age 70 years) receiving anti-myeloma therapy in Germany and Italy from November 2017 through February 2018 were analyzed. HRQoL was assessed using validated questionnaires (Work Productivity and Activity Impairment [WPAI], European Organization for Research and Treatment of Cancer Quality of Life Questionnaire -C30 and -MY20). Physical pain severity was assessed during clinical consultation by a single question, asking patients to describe their pain as "no pain," "mild," "moderate," or "severe." Associations between patient-reported pain severity and HRQoL scores were assessed by analysis of variance or χ

conclusionHigher pain severity, based on a single self-report question, was associated with poorer HRQoL in patients with MM, thereby supporting the clinical relevance of directly asking patients to self-evaluate their pain severity.

Indexed as

Quality of LifeAdultAgedCancer PainCross-Sectional StudiesFemaleHumansMaleMiddle AgedMultiple MyelomaPain MeasurementSeverity of Illness IndexSurveys and Questionnairespainpatient-reportedquality of life

Identifiers

PMID34110106
PMCPMC8789609
OpenAlexW3167837385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.