Evidence map›Paper›PMID 34110101›Full record

SynthesisCancer medicine2021

Prehabilitation exercise therapy for cancer: A systematic review and meta-analysis.

Christina M Michael, Eric J Lehrer, Kathryn H Schmitz, Nicholas G Zaorsky

4 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 83 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 12 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06785051 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of AI-Based Physiotherapy on Mandibular Mobility, Shoulder Function, Whole-Body Physical Function, and Quality of Life in Oral Cancer Patients

TypeinterventionalSponsorNational Taiwan University HospitalRan2025 to 2027Enrolled100ConditionsOral CancerArmsAI-based physiotherapy, Conventional physiotherapy, Scar management
NCT07237672 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of AI Based Physiotherapy on Mandibular Mobility Shoulder Function Whole Body Physical Function Quality of Life and Return to Work in Oral Cancer Patients: 3- and 9-Month Postintervention Follow-Up

TypeinterventionalSponsorNational Taiwan University HospitalRan2025 to 2027Enrolled65ConditionsOral CancerArmsAI-based physiotherapy follow-up assessments, conventional physiotherapy follow-up assessments
NCT07240584 nacompletednot on this mapstarted 2024, after this paper: background citation

The Impact of Exercise Prehabilitation on Upper Extremity Range of Motions, Functionality and Quality of Life in Breast Cancer Survivors: A Prospective Clinical Trial

TypeinterventionalSponsorUniversity of Health Sciences Balikesir Hospital Eduation and ResearchRan2024 to 2025Enrolled30ConditionsBreast Cancer, Shoulder Dysfunction, Quality of Life, Postoperative RecoveryArmsExercise-Based Prehabilitation Program
NCT07390071 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy

TypeinterventionalSponsorUniversity of UtahRan2025 to 2029Enrolled40ConditionsLymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity SyndromeArmsHome Automated Telemanagement (HAT) Patient Unit
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 12 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Physical prehabilitation in patients with breast cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  7. Pooled it
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  9. Effects of unimodal or multimodal prehabilitation on patients undergoing surgery for esophagogastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  10. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  11. Pooled it
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  14. Trial
  15. Review
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Christina M MichaelPenn State College of Medicine, Hershey, PA, USA.ORCID 0000-0003-1973-5763
Eric J LehrerDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1216-6230
Kathryn H SchmitzDepartment of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA.
Nicholas G ZaorskyDepartment of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA.ORCID 0000-0002-4932-1986
Penn State Milton S. Hershey Medical Center · USIcahn School of Medicine at Mount Sinai · USPennsylvania State University · US

Funding

American Cancer Society CSDG-CCE 133738NCI NIH HHS L30 CA231572
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine the impact of prehabilitation exercise intervention with respect to (1) acceptability, feasibility, and safety; and (2) physical function, measured by 6-minute-walk test (6MWT). DATA SOURCES: PRISMA guidelines were used to systematically search PubMed, Embase, and CINAHL databases evaluating prehabilitation exercise interventions. STUDY SELECTION: The inclusion criteria were studies investigating patients who underwent surgery for their cancer and underwent prehabilitation exercise. DATA EXTRACTION AND SYNTHESIS: Guidelines were applied by independent extraction by multiple observers. Data were pooled using a random-effects model. MAIN OUTCOME(S) AND MEASURE(S): Acceptability, feasibility, and safety rates were calculated. 6MWT (maximum distance a person can walk at their own pace on a hard, flat surface, measured in meters, with longer distance indicative of better performance status) was compared using two arms using the DerSimonian and Laird method.

resultsObjective 1. Across 21 studies included in this review, 1564 patients were enrolled, 1371 (87.7%) accepted the trial; of 1371, 1230 (89.7% feasibility) completed the intervention. There was no grade 3+ toxicities. Objective 2. Meta-analysis of five studies demonstrated a statistically significant decrease in 6MWT distance postoperatively in the control group (mean difference = +27.9 m; 95% confidence interval (CI): 9.3; 46.6) and a significant improvement postoperatively in the prehabilitation group (mean difference = -24.1 m; 95% CI: -45.7; -2.6). Meta-analysis demonstrated improvements in 6MWT distance 4-8 weeks postoperatively in the prehabilitation group compared to the control group (mean difference = -58.0 m, 95% CI: -92.8; -23.3). CONCLUSIONS AND RELEVANCE: Prehabilitation exercise for cancer patients undergoing surgery was found to be safe, acceptable, and feasible with a statistically significant improvement in the 6MWT, indicating that prehabilitation can improve postoperative functional capacity.

Indexed as

Preoperative ExerciseBiasFeasibility StudiesHumansNeoplasmsPatient ParticipationPhysical Functional PerformanceWalk Testcolorectal cancerlung cancermeta-analysissurgerysurgical therapy

Identifiers

PMID34110101
PMCPMC8267161
OpenAlexW3169266653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.