Evidence map›Paper›PMID 34110099›Full record

ArticleESC heart failure2021

Readmission following both cardiac and non-cardiac acute dyspnoea is associated with a striking risk of death.

Kamilė Čerlinskaitė, Alexandre Mebazaa, Raphaël Cinotti, Michael Matthay, Desiree N Wussler, Etienne Gayat, Vytautas Juknevičius, Nikola Kozhuharov, Julia Dinort, Eleni Michou and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 6 institutions in 5 countries.

Kamilė ČerlinskaitėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-6753-9356
Alexandre MebazaaInserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), Paris, France.
Raphaël CinottiDepartment of Anesthesia and Critical Care, Hôpital Laennec, University Hospital of Nantes, Saint-Herblain, France.
Michael MatthayDepartment of Medicine and Anesthesia, University of California, San Francisco, CA, USA.
Desiree N WusslerCardiology Department and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Etienne GayatInserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT), Paris, France.
Vytautas JuknevičiusClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Nikola KozhuharovCardiology Department and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Julia DinortCardiology Department and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Eleni MichouCardiology Department and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Danielle M GualandroCardiology Department and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Eglė PalevičiūtėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Irina Alitoit-MarroteCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Denis KablučkoCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Loreta BagdonaitėInstitute of Biomedical Science, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Mindaugas BalčiūnasClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Dovilė VaičiulienėLithuanian University of Health Sciences, Kaunas, Lithuania.
Ieva JonauskienėLithuanian University of Health Sciences, Kaunas, Lithuania.
Justina MotiejūnaitėLithuanian University of Health Sciences, Kaunas, Lithuania.
Kęstutis StašaitisLithuanian University of Health Sciences, Kaunas, Lithuania.
Audrys KukulskisLithuanian University of Health Sciences, Kaunas, Lithuania.
Šarūnas DamalakasLithuanian University of Health Sciences, Kaunas, Lithuania.
Aleksandras LaucevičiusClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Christian MuellerCardiology Department and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Basel, Switzerland.
Aušra KavoliūnienėLithuanian University of Health Sciences, Kaunas, Lithuania.
Jelena ČelutkienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
GREAT network
Vilnius University · LTLithuanian University of Health Sciences · LTUniversity of Basel · CHInserm · FRHôpital Laennec · FRUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsReadmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac and non-cardiac causes. METHODS AND

resultsDerivation cohort (1371 patients from the LEDA study) and validation cohort (1986 patients from the BASEL V study) included acute dyspnoea patients admitted to the emergency department. Cox regression analysis was used to determine the association of 6 month readmission and the risk of 1 year all-cause mortality in AHF and non-AHF patients and those readmitted due to cardiovascular and non-cardiovascular causes. In the derivation cohort, 666 (49%) of patients were readmitted at 6 months and 282 (21%) died within 1 year. Six month readmission was associated with an increased 1 year mortality risk in both the derivation cohort [adjusted hazard ratio (aHR) 3.0 (95% confidence interval, CI 2.2-4.0), P < 0.001] and the validation cohort (aHR 1.8, 95% CI 1.4-2.2, P < 0.001). The significant association was similarly observed in AHF (aHR 3.2, 95% CI 2.1-4.9, P < 0.001) and other causes of acute dyspnoea (aHR 2.9, 95% CI 1.9-4.5, P < 0.001), and it did not depend on the aetiology [aHR 2.2, 95% CI 1.6-3.1 for cardiovascular readmissions; aHR 4.1, 95% CI 2.9-5.7 for non-cardiovascular readmissions (P < 0.001 for both)] or timing of readmission. CONCLUSION​S: Our study demonstrated a long-lasting detrimental association between readmission and death in AHF and non-AHF patients with acute dyspnoea. These patients should be considered 'vulnerable patients' that require personalized follow-up for an extended period.

Indexed as

Heart FailurePatient ReadmissionCohort StudiesDyspneaHospitalizationHumansAcute dyspnoeaAcute heart failureEmergency departmentMortalityReadmissionVulnerable phase

Identifiers

PMID34110099
PMCPMC8318470
OpenAlexW3165952654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.