ArticleHuman brain mapping2021
Function-structure coupling: White matter functional magnetic resonance imaging hyper-activation associates with structural integrity reductions in schizophrenia.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Brain imaging reveals hierarchical topology changes and stage-dependent impairments in autoimmune encephalitis.Journal of neurology · 2026Article
- Disruption of prefrontal and superior temporal gyrus white matter networks in antipsychotic-treated schizophrenia with comorbid metabolic syndrome.Frontiers in psychiatry · 2026Article
- Investigation of the large-scale white-matter functional networks in spinocerebellar ataxia type 3.Quantitative imaging in medicine and surgery · 2025Article
- Observational
- A narrative literature review of white matter microstructure in individuals at clinical high risk for psychosis.Psychoradiology · 2025Review
- Altered static and dynamic functional connectivity in major depressive disorder accompanied by high anxiety: evidence from the REST-meta-MDD consortium.Frontiers in psychiatry · 2025Article
- Exploring Schizophrenia Classification Through Multimodal MRI and Deep Graph Neural Networks: Unveiling Brain Region-Specific Weight Discrepancies and Their Association With Cell-Type Specific Transcriptomic Features.Schizophrenia bulletin · 2024Article
- Structure-function coupling in macroscale human brain networks.Nature reviews. Neuroscience · 2024Review
- Continuous Dictionary of Nodes Model and Bilinear-Diffusion Representation Learning for Brain Disease Analysis.Brain sciences · 2024Article
- Altered functional-structural coupling may predict Parkinson's patient's depression.Brain structure & function · 2024Article
- Low-frequency rTMS induces modifications in cortical structural connectivity - functional connectivity coupling in schizophrenia patients with auditory verbal hallucinations.Human brain mapping · 2024Article
- Functional organization of the human corpus callosum unveiled with BOLD-fMRI gradients.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Females exhibit smaller volumes of brain activation and lower inter-subject variability during motor tasks.Scientific reports · 2023Article
- Structure-function coupling in white matter uncovers the abnormal brain connectivity in Schizophrenia.Translational psychiatry · 2023Article
- Brain structure-function coupling associated with cognitive impairment in cerebral small vessel disease.Frontiers in neuroscience · 2023Review
- Resting-State Neural-Activity Alterations in Subacute Aphasia after Stroke.Brain sciences · 2022Article
- Imaging functional neuroplasticity in human white matter tracts.Brain structure & function · 2022Article
- The Association Between Emotion Recognition, Affective Empathy, and Structural Connectivity in Schizophrenia Patients.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
White matter (WM) microstructure deficit may be an underlying factor in the brain dysconnectivity hypothesis of schizophrenia using diffusion tensor imaging (DTI). However, WM dysfunction is unclear in schizophrenia. This study aimed to investigate the association between structural deficits and functional disturbances in major WM tracts in schizophrenia. Using functional magnetic resonance imaging (fMRI) and DTI, we developed the skeleton-based WM functional analysis, which could achieve voxel-wise function-structure coupling by projecting the fMRI signals onto a skeleton in WM. We measured the fractional anisotropy (FA) and WM low-frequency oscillation (LFO) and their couplings in 93 schizophrenia patients and 122 healthy controls (HCs). An independent open database (62 schizophrenia patients and 71 HCs) was used to test the reproducibility. Finally, associations between WM LFO and five behaviour assessment categories (cognition, emotion, motor, personality and sensory) were examined. This study revealed a reversed pattern of structure and function in frontotemporal tracts, as follows. (a) WM hyper-LFO was associated with reduced FA in schizophrenia. (b) The function-structure association was positive in HCs but negative in schizophrenia patients. Furthermore, function-structure dissociation was exacerbated by long illness duration and severe negative symptoms. (c) WM activations were significantly related to cognition and emotion. This study indicated function-structure dys-coupling, with higher LFO and reduced structural integration in frontotemporal WM, which may reflect a potential mechanism in WM neuropathologic processing of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.