ArticleMovement disorders : official journal of the Movement Disorder Society2021
Functional Connectivity of Vermis Correlates with Future Gait Impairments in Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Neuroimaging of Parkinson's Disease
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Levodopa-induced dyskinesia is associated with worse gait and balance in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Early diagnosis of Alzheimer's Disease: Graph theoretical analysis of cerebellar network features based on 18F-AV45 PET.PloS one · 2026Article
- Connectome-based predictive modelling predicts frailty levels in older adults.bioRxiv : the preprint server for biology · 2025Article
- Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.NPJ Parkinson's disease · 2025Article
- Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity.Brain imaging and behavior · 2025Article
- Brain network pathophysiology in dystonia.Dystonia (Lausanne, Switzerland) · 2025Article
- White Matter Fiber Bundle Alterations Correlate with Gait and Cognitive Impairments in Parkinson’s Disease based on HARDI DataCurrent medical imaging · 2025Article
- Connectome-based predictive modeling of grip strength: a marker of physical frailty.Frontiers in neuroscience · 2025Article
- Therapeutic Intervention for Trunk Control Impairments in Central Nervous System Disorders: A Comprehensive Review of Methods and Efficacy.Progress in rehabilitation medicine · 2025Review
- Review
- Cerebellum in Alzheimer's disease and other neurodegenerative diseases: an emerging research frontier.MedComm · 2024Review
- Imbalance and gait impairment in Parkinson's disease: discussing postural instability and ataxia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Cerebellar activity in PINK1 knockout rats during volitional gait.Brain communications · 2024Article
- Cerebellar activity in hemi-parkinsonian rats during volitional gait and freezing.Brain communications · 2024Article
- Abnormal cerebellum connectivity patterns related to motor subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Cerebellar alterations in Parkinson's disease with postural instability and gait disorders.Journal of neurology · 2023Article
- Article
- Cerebellar functional connectivity change is associated with motor and neuropsychological function in early stage drug-naïve patients with Parkinson's disease.Frontiers in neuroscience · 2023Article
- Instrumented gait analysis defines the walking signature of CACNA1A disorders.Journal of neurology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDysfunction of cerebellar vermis contributes to gait abnormalities in multiple conditions and may play a key role in gait impairment in Parkinson's disease (PD).
objectiveThe purpose of this study was to investigate whether altered resting-state functional connectivity of the vermis relates to subsequent impairment of specific domains of gait in PD.
methodsWe conducted morphometric and resting-state functional connectivity MRI analyses contrasting 45 PD and 32 age-matched healthy participants. Quantitative gait measures were acquired with a GAITRite walkway at varying intervals after functional connectivity data acquisition.
resultsAt baseline, PD participants had significantly altered functional connectivity between vermis and sensorimotor cortex compared with controls. Altered vermal functional connectivity with bilateral paracentral lobules correlated with subsequent measures of variability in stride length, step time, and single support time after controlling for confounding variables including the interval between imaging and gait measures. Similarly, altered functional connectivity between vermis and left sensorimotor cortex correlated with mean stride length and its variability. Vermis volume did not relate to any gait measure. PD participants did not differ from controls in vermis volume or cortical thickness at the site of significant regional clusters. Only altered lobule V:sensorimotor cortex functional connectivity correlated with subsequent gait measures in exploratory analyses involving all the other cerebellar lobules.
conclusionsThese results demonstrate that abnormal vermal functional connectivity with sensorimotor cortex, in the absence of relevant vermal or cortical atrophy, correlates with subsequent gait impairment in PD. Our data reflect the potential of vermal functional connectivity as a novel imaging biomarker of gait impairment in PD. © 2021 International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.