Evidence map›Paper›PMID 34109620›Full record

ArticleDevelopmental medicine and child neurology2021

Early concerns in parents of infants at risk for autism.

Amanda T Tran, Mithi Del Rosario, Erin Nosco, Yihao Li, Damla Senturk, Nicole M Mcdonald, Rujuta B Wilson, Mirella Dapretto, Shafali S Jeste

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental medicine and child neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Amanda T TranDavid Geffen School of Medicine at the University of California, Los Angeles, CA, USA.ORCID 0000-0001-8179-1155
Mithi Del RosarioDavid Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Erin NoscoSemel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.
Yihao LiDepartment of Biostatistics, University of California, Los Angeles, CA, USA.
Damla SenturkDepartment of Biostatistics, University of California, Los Angeles, CA, USA.
Nicole M McdonaldSemel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.
Rujuta B WilsonSemel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.
Mirella DaprettoSemel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.
Shafali S JesteSemel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2007 to 2021
$32.0M
Functional Data Analysis for High-Dimensional Biobehavioral DataR01MH122428 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SENTURK, DAMLA, TELESCA, DONATELLO · 2020 to 2024
$1.8M
Quantification of Infant Motor Development to Predict Risk for Neurodevelopmental DisordersK23HD099275 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WILSON, RUJUTA BHATT · 2020 to 2024
$887k
NICHD NIH HHS K23 HD099275NICHD NIH HHS P50 HD055784NIMH NIH HHS R01 MH122428
6 · The paper itself

Abstract

aimTo examine parental concerns about children at increased familial risk (i.e. high risk) of developing autism spectrum disorder (ASD) in early infancy.

methodASD-related and general parental concerns were prospectively collected for 76 infants at ages 1.5, 3, 6, 9, 12, and 18 months. Outcome classification was determined at 36 months. Analyses included generalized linear mixed models and qualitative evaluation of parental concerns in relation to risk status (high vs low risk) and outcome classification within the high-risk group (atypically developing vs typically developing) over time.

resultsMost parents had no concerns at 1.5 (high risk 71%, low risk 87%) and 3 months (high risk 77%, low risk 86%). Beginning at 6 months, parents of high-risk infants reported more ASD-related (p<0.001) and general concerns (p=0.003) than parents of low-risk infants. Beginning at 12 months, parents of high-risk atypically developing infants reported more ASD-related concerns than parents of high-risk typically developing infants (p=0.013).

interpretationClinicians should elicit parental concerns and provide support, as parents are worried about their high-risk infants by age 6 months. Additionally, parents' abilities to identify concerns that are suggestive of ASD by age 12 months may aid in earlier screening and intervention. What this paper adds Most parents did not report concerns during early infancy. By 6 months, parents of high-risk infants reported autism spectrum disorder (ASD)-related and general concerns. By 12 months, parents of high-risk atypically developing infants identified ASD-related concerns.

Indexed as

Age FactorsAnxietyAutism Spectrum DisorderChild, PreschoolFemaleHumansInfantMaleParentsProspective StudiesRisk Factors

Identifiers

PMID34109620
PMCPMC8666093
OpenAlexW3170134259

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.