ArticleCerebellum (London, England)2022
Mapping the Cerebellar Cognitive Affective Syndrome in Patients with Chronic Cerebellar Strokes.
Article in Cerebellum (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Prevalence of Cerebellar Cognitive Affective Syndrome in Patients with Cerebellar Disorders: A Systematic Review and Meta-Analysis.Cerebellum (London, England) · 2026Pooled it
- Motor Improvements Following Non-Invasive Brain Stimulation with kTMP: A Case Study of Cerebellar Stroke.Cerebellum (London, England) · 2026Article
- Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Motor and Cognitive Improvements Following Non-Invasive Brain Stimulation with kTMP: A Case Study of Cerebellar Stroke.Research square · 2026Article
- Cerebellar Contributions to Cognitive Affective Function and Postural Tremor in Neurological Wilson's Disease.Cerebellum (London, England) · 2026Article
- Cerebellar cognitive affective syndrome (Schmahmann syndrome) following isolated cerebellar infarction.Dementia & neuropsychologia · 2026Article
- The Italian Standardization of the Cerebellar Cognitive Affective/Schmahmann Syndrome Scale: Cognitive Profiling in a Healthy, Heterogeneous Population.Cerebellum (London, England) · 2025Article
- The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale: Updates and Insights.Cerebellum (London, England) · 2025Article
- Amplitude of low-frequency fluctuation (ALFF) alterations in heart transplant patients with cognitive impairment: a resting-state fMRI study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version.Journal of neurology · 2025Article
- Cerebellar-cerebral circuits functional connectivity in patients with cognitive impairment after basal ganglia stroke: a pilot study.Frontiers in aging neuroscience · 2025Article
- Cerebellar cognitive affective syndrome in patients with spinocerebellar ataxia type 10.PloS one · 2025Article
- Shared and distinct brain activation patterns of acupoints HT7, ST36, and KI4: a task-based fMRI study.Frontiers in neurology · 2025Article
- Psychomotor and non-motor correlates of cognition in spinocerebellar ataxias Types 1, 2, 3, and 6.Brain communications · 2025Article
- Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study.Journal of neurology · 2024Article
- Associating Disrupted Intrinsic Functional Networks with Cognitive and Socio-Affective Skills Following Cerebellar Stroke.Cerebellum (London, England) · 2024Article
- The Cerebellar Cognitive Affective/Schmahmann Syndrome Scale in Spinocerebellar Ataxias.Cerebellum (London, England) · 2024Article
- The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia.Cerebellum (London, England) · 2024Article
- Reduced cerebral blood flow and cognitive dysfunction following isolated cerebellar infarction: two case reports.The Journal of international medical research · 2024Article
- Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the "language" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS.
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Registered trials
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