Evidence map›Paper›PMID 34109511›Full record

ArticleAnnals of surgical oncology2021

Impact of Nerve-Sparing Status on Positive Surgical Margin Location and Biochemical Recurrence in Patients with Prostate Cancer Post Radical Prostatectomy.

Yoshinori Matsuda, Shintaro Narita, Teppei Okubo, Koji Mitsuzuka, Shingo Hatakeyama, Atsushi Koizumi, Takuya Koie, Sadafumi Kawamura, Tatsuo Tochigi, Akihiro Ito and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Clinical risk prediction model and external validation of positive surgical margin in laparoscopic radical prostatectomy based on MRI lesion location.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yoshinori MatsudaDepartment of Urology, Akita University School of Medicine, Akita, Japan.
Shintaro NaritaDepartment of Urology, Akita University School of Medicine, Akita, Japan. nari6202@gipc.akita-u.ac.jp.
Teppei OkuboDepartment of Urology, Tohoku University School of Medicine, Sendai, Japan.
Koji MitsuzukaDepartment of Urology, Tohoku University School of Medicine, Sendai, Japan.
Shingo HatakeyamaDepartment of Urology, Hirosaki University School of Medicine, Hirosaki, Japan.
Atsushi KoizumiDepartment of Urology, Akita University School of Medicine, Akita, Japan.
Takuya KoieDepartment of Urology, Gifu University School of Medicine, Gifu, Japan.
Sadafumi KawamuraDepartment of Urology, Miyagi Cancer Center, Miyagi, Japan.
Tatsuo TochigiDepartment of Urology, Miyagi Cancer Center, Miyagi, Japan.
Akihiro ItoDepartment of Urology, Tohoku University School of Medicine, Sendai, Japan.
Chikara OyamaDepartment of Urology, Hirosaki University School of Medicine, Hirosaki, Japan.
Yoichi AraiDepartment of Urology, Miyagi Cancer Center, Miyagi, Japan.
Tomonori HabuchiDepartment of Urology, Akita University School of Medicine, Akita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was designed to assess the relationship between nerve-sparing (NS) status, positive surgical margin (PSM) location, and biochemical recurrence (BCR) based on a multicenter, radical prostatectomy (RP) database.

methodsWe retrospectively reviewed data from 726 patients who underwent RP without any neoadjuvant or adjuvant treatment between 2010 and 2014. We statistically assessed the impact of NS sides on PSM location and BCR.

resultsPSM rates were 21.9% in the 726 patients studied, 13.2% in patients with ≤pT2, and 46.8% in patients with ≥pT3. Regarding PSM locations, the anterior-apex (AA) was the most common site for PSM (43.3%). After adjusting for confounding factors, bilateral nerve sparing (BNS) had a significantly higher odds ratio of PSM than the absence of NS did (odds ratio [OR] 3.04, 95% confidence interval [CI] 1.85-4.99). In the UNS RP in patients with ≤pT2, non-AA PSM on the non-NS side was significantly higher than that on the NS side (92.9% vs. 45.5%, p = 0.009). In all patients, 5.8% experienced BCR during a median follow-up of 43.5 months. PSM was significantly associated with BCR-free survival in patients with ≤pT2 (p = 0.013), but not in patients with ≥pT3 (p = 0.185). Non-AA PSM at the non-NS side was an independent risk factor for BCR (hazard ratio [HR] 2.56, 95% confidence interval [CI] 1.12-5.85), whereas AA PSMs, including NS/non-NS sides and non-AA PSM at the NS side, were not associated with BCR-free survival.

conclusionsAvoidance of non-AA PSM on the non-NS side may be rather important for maintaining BCR-free survival after RP.

Indexed as

Margins of ExcisionProstatic NeoplasmsHumansMaleNeoplasm Recurrence, LocalProstatectomyProstate-Specific AntigenRetrospective StudiesProstate-Specific Antigen

Identifiers

PMID34109511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.