Evidence map›Paper›PMID 34109425›Full record

ArticleMolecular medicine reports2021

miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B.

Chunrong Wu, Xiaohu Liu, Bo Li, Guiying Sun, Chunfang Peng, Debing Xiang

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  10. Regulation of Metastasis and Growth of Colorectal CancerRecent patents on anti-cancer drug discovery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chunrong WuDepartment of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing 402260, P.R. China.
Xiaohu LiuDepartment of Gastrointestinal Surgery, Jiangjin Central Hospital of Chongqing, Chongqing 402260, P.R. China.
Bo LiDepartment of Cardiology, Jiangjin Central Hospital of Chongqing, Chongqing 402260, P.R. China.
Guiying SunDepartment of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing 402260, P.R. China.
Chunfang PengDepartment of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing 402260, P.R. China.
Debing XiangDepartment of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing 402260, P.R. China.
Jiangjin Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer metastasis and recurrence are major causes of poor survival in patients with colorectal cancer (CRC). Therefore, the biological behavior of microRNA (miR)‑451 in CRC deserves further investigation. Reverse transcription‑quantitative PCR was applied to measure the relative expression of miR‑451 in blood serum specimens from patients with CRC and CRC cells.

Indexed as

AgedAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationColorectal NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiceMice, NudeMicroRNAsMiddle AgedMicroRNAsMIRN451 microRNA, humanRepressor ProteinsSAMD4B protein, humanapoptosiscolorectal cancermigrationmiR‑451proliferationSAMD4B

Identifiers

PMID34109425
PMCPMC8188639
OpenAlexW3171727557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.