ArticleBrain multiphysics2021
An inverse modelling study on the local volume changes during early morphoelastic growth of the fetal human brain.
Article in Brain multiphysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A Physics-Informed Deep Learning Deformable Medical Image Registration Method Based on Neural ODEs.International journal of computer vision · 2025Article
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- Effects of stress-dependent growth on evolution of sulcal direction and curvature in models of cortical folding.Brain multiphysics · 2023Article
- Exploring the multiphysics of the brain during development, aging, and in neurological diseases.Brain multiphysics · 2023Article
- Brain aging mechanisms with mechanical manifestations.Mechanisms of ageing and development · 2021Review
- Brain Shape Changes Associated With Cerebral Atrophy in Healthy Aging and Alzheimer's Disease.Frontiers in Mechanical Engineering · 2021Article
- System Inference Via Field Inversion for the Spatio-Temporal Progression of Infectious Diseases: Studies of COVID-19 in Michigan and Mexico.Archives of computational methods in engineering : state of the art reviews · 2021Article
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4 authors.
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Abstract
We take a data-driven approach to deducing the local volume changes accompanying early development of the fetal human brain. Our approach uses fetal brain atlas MRI data for the geometric changes in representative cases. Using a nonlinear continuum mechanics model of morphoelastic growth, we invert the deformation obtained from MRI registration to arrive at a field for the growth deformation gradient tensor. Our field inversion uses a combination of direct and adjoint methods for computing gradients of the objective function while constraining the optimization by the physics of morphoelastic growth. We thus infer a growth deformation gradient field that obeys the laws of morphoelastic growth. The errors between the MRI data and the forward displacement solution driven by the inverted growth deformation gradient field are found to be smaller than the reference displacement by well over an order of magnitude, and can be driven even lower. The results thus reproduce the three-dimensional growth during the early development of the fetal brain with controllable error. Our findings confirm that early growth is dominated by in plane cortical expansion rather than thickness increase.
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