ArticleJournal of oral microbiology2019
Determining bacterial and host contributions to the human salivary metabolome.
Article in Journal of oral microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review.Clinical and experimental dental research · 2025Pooled it
- Salivary metabolomics for the diagnosis of periodontal diseases: a systematic review with methodological quality assessment.Metabolomics : Official journal of the Metabolomic Society · 2021Pooled it
- Interactions between taste and oral microbiome: mechanisms and implications for oral and systemic diseases.Journal of oral microbiology · 2026Review
- A repository of the salivary metabolome and its key drivers in 1436 European children.EBioMedicine · 2025Article
- Comprehensive GC/MS Profiling of Volatile Organic Compounds in Whole and Glandular Saliva Using MonoTrap Micro-Extraction.Metabolites · 2025Article
- Metabolic Features of Saliva Before and After Breast Cancer Surgery.Metabolites · 2025Article
- Salivary BCAA, Glutamate, Glutamine and Urea as Potential Indicators of Nitrogen Metabolism Imbalance in Breast Cancer.Current issues in molecular biology · 2025Article
- Radiation-induced changes in salivary metabolite profile and pathways in head and neck cancer patients.Clinical oral investigations · 2025Article
- The role of salivary metabolomics in chronic periodontitis: bridging oral and systemic diseases.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Influence of Parotid Saliva Composition on Phosphate Species' Chemical State in Relation to Dental Caries.Clinical and experimental dental research · 2025Article
- The Association between Salivary Metabolites and Gingival Bleeding Score in Healthy Subjects: A Pilot Study.International journal of molecular sciences · 2024Article
- Comparative analysis of oral saliva microbiomes and metabolites in Han population at different altitudes.Frontiers in microbiology · 2024Article
- Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress.Scientific reports · 2023Article
- Oral Sources of Salivary Metabolites.Metabolites · 2023Review
- NMR-Based Metabolomics Demonstrates a Metabolic Change during Early Developmental Stages from Healthy Infants to Young Children.Metabolites · 2023Article
- Review
- Salivary Metabolomics in the Diagnosis and Monitoring of Neurodegenerative Dementia.Metabolites · 2023Review
- Salivary microbiome and metabolome analysis of severe early childhood caries.BMC oral health · 2023Article
- Multiomics analysis reveals the genetic and metabolic characteristics associated with the low prevalence of dental caries.Journal of oral microbiology · 2023Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSalivary metabolomics is rapidly advancing. AIM AND
methodsTo determine the extent to which salivary metabolites reflects host or microbial metabolic activity whole-mouth saliva (WMS), parotid saliva (PS) and plasma collected contemporaneously from healthy volunteers were analysed by
resultsWMS contained abundant short-chain fatty acids (SCFAs), which were minimal in PS and plasma. WMS spectral exhibited greater inter-individual variation than those of PS or plasma (6.7 and 3.6 fold, respectively), likely reflecting diversity of microbial metabolomes. WMS bacterial load correlated strongly with SCFA levels. Additional WMS metabolites including amines, amino acids and organic acids were positively correlated with bacterial load. Lactate, urea and citrate appeared to enter WMS via PS and the circulation. Urea correlated inversely with WMS bacterial load.
conclusionsOral microbiota contribute significantly to the WMS metabolome. Several WMS metabolites (lactate, urea and citrate) are derived from the host circulation. WMS may be particularly useful to aid diagnosis of conditions reflective of dysbiosis. WMS could also complement other gastrointestinal fluids in future metabolomic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.