Evidence map›Paper›PMID 34108968›Full record

ArticleFrontiers in immunology2021

Oral

Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Michael Hensel, Fouad Kandeel, Mohamed I Husseiny

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Deficiency in theMicroorganisms · 2025
    Article
  2. Vaccines · 2025
    Review
  3. Role ofMicroorganisms · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Engineering live attenuated vaccines: Old dogs learning new tricks.Journal of translational autoimmunity · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Jacob CobbDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.
Jeffrey RawsonDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.
Nelson GonzalezDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.
Michael HenselDivision of Microbiology, University of Osnabrück, Osnabrück, Germany.
Fouad KandeelDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.
Mohamed I HusseinyDepartment of Translational Research & Cellular Therapeutics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, United States.
City Of Hope National Medical Center · USOsnabrück University · DEZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A therapy that includes an oral vaccine for type 1 diabetes (T1D) using live attenuated

Indexed as

Genetic VectorsMutationAcyltransferasesAdministration, OralAnimalsAntibodies, MonoclonalBacterial ProteinsBiomarkersBlood GlucoseCD3 ComplexDiabetes Mellitus, Type 1Disease Models, AnimalFemaleInsulinInterleukin-10MiceAcyltransferasesAntibodies, MonoclonalBacterial ProteinsBiomarkersBlood GlucoseCD3 ComplexIL10 protein, mouseInsulinInterleukin-10preproinsulinProtein PrecursorsTgfb1 protein, mouseTransforming Growth Factor beta1Vaccines, AttenuatedVaccines, DNAautoantigensdiabetes reversal and preventionimmunomodulatorimmunotherapyoral vaccinationSalmonella msbB mutanttype 1 diabetes

Identifiers

PMID34108968
PMCPMC8181392
OpenAlexW3164988013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.